The standardization of CRRT fluids using commercially available products improved a medical center's compliance with patient safety standards and yielded substantial cost savings.
e18036 Background: Significant disparities exist across the head and neck cancer (HNC) care continuum in presentation, treatment, and survival. Along with demographic factors such as race or ethnicity, tumor-specific molecular signatures may play a role in these differences. In the United States, the current body of literature mainly highlights molecular contrasts between Black and White patients. Here, we further investigate the molecular profiles of Black and White patients with HNC and add to the literature by comparing additional racial/ethnic groups in a large, real-world cohort. Methods: De-identified records of patients with a primary diagnosis of HNC who underwent Tempus xT testing (Tempus Labs, Chicago, IL) were selected from the Tempus Database. Those with squamous cell histology and self-reported race were selected for retrospective analysis. Briefly, Tempus xT is a targeted, tumor/normal-matched panel that detects single-nucleotide variants, insertions and/or deletions, and copy number variants in 648 genes, as well as chromosomal rearrangements in 22 genes with high sensitivity and specificity. Tumor mutational burden (TMB) was calculated by dividing the number of nonsynonymous mutations by the megabase size of the panel. Results: Among the 749 patients included, most identified as Non-Hispanic/Latino (NHL) White (n = 570), while 62 identified as NHL Black, 44 as NHL Asian/Pacific Islander (API), 21 as NHL of other races, and 52 as Hispanic/Latino of any race. Age at diagnosis differed between races ( P= 0.009). Oral cavity was the most common subsite in our cohort (N = 306, 41%). TMB also differed among races ( P= 0.018), with Black patients demonstrating the highest TMB (median = 4.6 mut/Mb [3.0-6.2]) and API the lowest (median = 2.3 mut/Mb [1.5-4.2]). Black patients had higher proportions of TP53 (76%), KMT2D (24%), and CTTN (15%) alterations (not significant across races). There were differences in the frequencies of OR4G11P (q = 0.031) and OR4F5 (q = 0.014) aberrations between races, with Black patients showing the highest frequencies (16% and 15%, respectively). The API population demonstrated higher frequencies of RASA1 (16%), MTAP (11%), CDKN2B (32%), and ERCC3 (11%) mutations (not significant across races). Additionally, there were differences in TERT mutations between races (q = 0.01), with API harboring the highest proportion of TERT co-mutations (52%). Conclusions: Overall, these results demonstrate that molecular profiles are heterogeneous across multiple racial/ethnic groups. Many of the alterations described here have been previously associated with outcomes in HNC. Accordingly, future investigations should aim to understand the effects of the activated pathways for clinical utility and investigate biomarkers to drive individualized treatment plans that result in equitable care.
Two Under the Indian Sun : Jon Godden, Rumer Godden. A few of her works were co-written with her older sister, novelist Jon Godden, including Two Under the Indian Sun, a memoir of the Goddens' childhood in a. Two Under the Indian Sun by Jon Godden-Reviews, Discussion. Two Under the Indian Sun, Jon Godden, Rumer Godden. Two Under the Indian Sun-AbeBooks 199pp., unpaginated b/white halftone plate section, plus an intext sketch illustration. Book clean. Minimal reading creases on mildly cocked spine. Illustrated ... Two Under the Indian Sun : Jon Godden, Rumer .-Book Depository In 1914, two small sisters-Jon and Rumer Godden-left London to return to India and their home in East Bengal. This book is their remembrance of the five years ... Colonial Strangers: Women Writing the End of the British Empire-Google Books Result Two Under the Indian Sun by Jon Godden, Rumer Godden. (Paperback 9780688074227) Rumer Godden-Wikipedia, the free encyclopedia Two Under the Indian Sun by Godden, Rumer and a great selection of similar Used, New and Collectible Books available now at AbeBooks.co.uk. Jon and Rumer Godden grew up in India during the days of the British Raj, and later both became best-selling and prolific authors. Jon wrote Shiva's Pigeons, ... TWO UNDER THE INDIAN SUN : An Evocative Memoir of the Days. Two Under The Indian Sun by Jon And Rumer Godden HCDJ 1966 in Books, Antiquarian & Collectible eBay. Benedict in the World: Portraits of Monastic Oblates-Google Books Result TWO UNDER THE INDIAN SUN by Godden, Jon and Rumer and a great selection of similar Used, New and Collectible Books available now at AbeBooks.com. The Indian Subcontinent in Literature for Children and Young .-Google Books Result 240 pp. Price of $5.50 on front flap of jacket. Two sisters' autobiography of their childhood in India in the early 20th century. Very near Fine book in a Very Good+ ... Two under the Indian sun, was merged with this page. Written byJon Godden. ISBN0333405854. 0 people like this topic. Harvard Library Open Metadata. Two Under the Indian Sun-Godden, Jon and Rumer Set in India, and concerned with her perennial theme of the transition from. of Sparrows (1955), Two Under the Indian Sun (1966), Shiva's Pigeons (1972), The ... Two under the Indian sun. [Jon Godden; Rumer Godden]-The Godden sisters have written of five years in their early lives when they were sent back to India to ... Two Under the Indian Sun: Jon Godden, Rumer .-Amazon.com Two under the Indian sun http://data.dm2e.eu/data/agent/cjh/lbilibrary/Godden_Jon_1906-1984. Two Under The Indian Sun by Jon and Rumer Godden HCDJ 1966. ?Rumer Godden Biography-eNotes.com This becomes clear in Two Under the Indian Sun, written with her older sister Jon Godden, an account of a five-year period of their childhood in the Bengal town. Rumer Godden-Obituary from Daily Telegraph (UK) Start by marking "Two Under the Indian Sun" as Want to Read:. In November 1914 two small sisters, Jon and Rumer Godden, returned to India. ... Jon and Rumer Godden spent the happiest part of their childhoo...
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