Background: Illicit, nonmedical use of opioid agonist medications such as methadone is an ongoing concern. Yet, few studies have examined nonmedical use of methadone by people who inject drugs (PWID).Objectives: This study describes the prevalence of nonmedical methadone use in a community sample of PWID and examines factors associated with recent use of nonmedical methadone.
Methods:A cross-sectional sample of PWID (N=777) was recruited using targeted sampling and interviewed in California (2011California ( -2013. Descriptive, bivariate, and multivariate logistic regression analyses were used to determine characteristics associated with nonmedical methadone use in the last 30 days. To determine if nonmedical methadone use was associated with overdose in the last 6 months, a separate multivariate analysis was conducted.Results: Among PWID sampled, 21% reported nonmedical methadone use in the last 30 days. In multivariate logistic regression analysis, nonmedical methadone use was associated with recent methadone maintenance treatment (adjusted odds ratio [AOR]= 2.
Highlights
Tumor lysis syndrome is a rare but deadly complication of solid tumors.
We suggest that tumor lysis syndrome is especially deadly when it results from high grade or metastatic endometrial cancers.
Consider prophylactic measures to prevent tumor lysis syndrome in high risk patients before initiating therapy.
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