Transient renal dysfunction has bee observed in some premature infants who received indomethacin to constrict patent ductus arteriosi, and it has been suggested that this complication may be dose related. Accordingly, the present study was designed to investigate the influence of high (7.5 mg/kg) and low (0.2 mg/kg) doses of indomethacin on effective renal blood flow, glomerular filtration rate, urine flow, sodium and potassium excretion and plasma levels of indomethacin in conscious newborn lambs studied continuously over a 24-hour period. When compared to control lambs, both indomethacin doses reduced effective renal blood flow significantly at 2–4 h, but only high doses significantly reduced renal blood flow at 22–24 h (6.5 ± 0.9 vs. 13.4 ± 1.4 ml/min/kg, respectively; p < 0.001). At 8–16 and 16–24 h after drug administration, urine flow was significantly lower than in the control group only in high-dose lambs (p < 0.05). During the 16 to 24-hour period, urine flow for control, low- and high-dose animals was 0.15 ± 0.01, 0.14 ± 0.01, and 0.08 ± 0.02 ml/min/kg, respectively. Glomerular filtration rate and sodium and potassium excretion rates were not affected by either indomethacin dose.
The pressure/volume changes during earlv (Ej), mid (M3) and late (L3) thirds of ejection were analyzed in 20 normal children (11). 7 aortic coarctation (Co), and 20 aortic stenosis (AS). Mean peak svstolic qradient was 30 mmHg in C o , and 31 in AS. Ejectjon fraction at E3, ~3 , and L3 were 0.33. 0.36 and 0.27 for 14: 0.35, 0.37 and 0.28 for Co; 0.24, 0.41 and 0.28 for AS. Tr;.lsion-time index (TTI) in mrnXo-sec, stroke index (SI) , output index (01) , ejection rate (SI/sec) and SI/TTI ratio in cc/mm~q-sec/m2 were obtained. ~~~e s e are summarized below (P values vs PI: *-<.05; **-< .001). In o=der to determine the-effect of cyanosis on platelet S U M V~~, experimental cyanosis was produced in dogs hy anastonosi~lg the left atrial apmndage to the main pulmonary artery. The six cyanotic animals used in this study had arth-ial 02 saturations of 71%-85% and elevated hematocrits. ~urvivai of platelets exchanged between cyanotic and control animals was detennined. Platelets from cvanotic dogs studied in control animals had a 69%-87t sliorter sunrival than the autologous PHL of the control animals. indicating an abnormality intrinsic to the platelet produced in the cyanotic do^. ?r'onnal platelets fmn control animals transfused into cyanotic dogs had the i d e n t i w reduced survival of autolo~ow platelets in that cyanotic animal, suggesting that some determinant of transfused platelet survival is extrinsic to the platelet. (litThree months after shunt closure in two dogs, the reduced Pl& has persisted. 16/56 infants (ages 2 wks to 6 mos) with isolated coarctation of the thoracic aorta presented with conqestive heart failure and severe systemic hypertension ranging from 210/140 to 150/80 mmHg. MEDICAL MANAGEMENT OF SEVERE SYSTEMICBecause of the surgical risks in symptomatic infants and the probability of recoarctation, conventional anticongestive medical management was instituted. The response to the anticongestive measures was markedly enhanced by diminishing afterload with chronic oral propranolol (.05-1.0 mg/kg/day) with maximal antihypertensive effects noted by 1-4 wks. Rebound hypertension was noted in 4 patients with propranolol withdrawal. This clinical response noted is consistent with high renin hyper tension. No complications related to beta blockade have been seen in the infants treated. From this data we conclude that the antihypertensive effects from propranolol far outweigh the negative inotropic effects in the treatment of coarctation of the aorta. Further, tilr trratment of sevcrc hypertension in infants with coarctation of the aorta may allow deferral of surgery to a more opt-imal size and clinical status. We have reviewed our recent experience with 10 young parlenrs requiring chronic cardiac pacinp. Details of the performance of the most recent two generators are summarized. Six patients required pacing for symptomatic congenital complete heart block, two for postoperative complete heart block. one for heart block associated with idiopathic myocardiopathy and one for the sick sinus syndrome. Pacemak...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.