SUMMARY The duodenal transmural potential difference (pd) has been studied in isolated vascularperfused preparations of canine stomach and duodenum. There was no quantitative correlation between the magnitude of the intraluminal pressure change and pd but fluctuations of pd in these preparations were related to duodenal slow wave activity. In this institution considerable experience has accumulated in the use of isolated vascular-perfused canine stomach and proximal intestine preparations (Ritchie and Hardcastle, 1973) in which propagated electrical activity and motility are preserved (Green
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