Understanding the interaction of gold nanoclusters with proteins has important ramifications in various fields. We present a study of the interaction between gold nanoclusters and lysozyme investigated using classical molecular dynamics and center-of-mass pulling simulations. The results reveal that the gold nanoclusters induce significant structural changes in lysozyme. Because the internal motions of lysozyme are related to its function, the changes in these internal motions have been quantified using principal component analysis of the molecular dynamics trajectories. The internal motions of lysozyme that are important for its function have been altered because of the interaction with the gold nanocluster. We have also explored how these induced changes in the lysozyme structure affect specific optical properties of the gold nanocluster using the complex polarization propagator method within the time-dependent density functional theory framework, which is of relevance for studies of the optical imaging of lysozyme using gold nanoclusters as molecular probes.
Self-medication is a common practice worldwide and the irrational use of the drugs is a major cause of concern. Self-medication is an issue with serious global implication. The current study aimed to determine the Knowledge, Attitude and Behavior of self-medication in college students. The Study site was Faculty of Engineering and Technology, (Engineering and Pharmacy department) Annamalai University, Annamalai Nagar, Tamil Nadu. The Study design was consisting of Cross sectional study. The total study population was 100 students (respondents), in the students 50 from Pharmacy (healthcare students) and other 50 from engineering students (non-healthcare students). Total study period of six months. All the data were collected by questionnaire, it was containing 30 questions both open and closed type questions. The questions were distributed to 50 healthcare and 50 non-healthcare students for getting information regarding self-medication. Since inappropriate self-medication has the potential to cause serious harm, not only to students themselves but also to those whom they suggest medication. Prevalence of self-medication was high due to minor illness. However, there is no significant association between prevalence and gender of respondents. Health care students are more awareness about self-medication. It helps to conduct counseling programs about the potential risk of self-medication, which can help to prevent the harms of un-prescribed medication.
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