This observational case series in 65 premenopausal women with abnormal uterine bleeding evaluated whether transvaginal ultrasound followed by saline infusion sonohysterography (SIS) prevented unnecessary hysteroscopy. Although SIS indicated that hysteroscopy was unnecessary in eight women, this benefit was offset by the invasive nature of the scan, the number of endometrial abnormalities falsely detected by SIS and the cost of the additional investigation.
Oral communication abstractsmarkers, alone and in combination, to predict PE. We measured serum markers using specific ELISAs. Results: Of 205 women recruited, 14 developed PE. PE cases were matched 1 : 2 to controls. The data were normally distributed after logarithmic transformation. All markers were significantly higher, except PlGF which was significantly lower, in women who subsequently developed PE. Data are presented as ROC areas for those variables which best predicted PE: UAD mean PI: 0.91 (CI:0.85-0.96); Results: 155 patients showed bilateral notching of the uterine artery. In the subsequent follow up 107 patients showed preeclampsia (blood pressure > 140/90+ proteinuria > 300 mg/dl): 32 patients (Group A) had late and 75 early preeclampsia (Group B). Five out of 32 patients of group A had bilateral notching of the uterine artery at 24 weeks, whereas 45 out of 75 patients of group B showed bilateral notching at 24 weeks (15.6% vs.60.0%; P < 0.05). TVR at 24 weeks' in the asymptomatic phase of the disease was 741 ± 260 dyn sec cm −5 in group A vs. 1605 ± 248 dyn sec cm −5 in group B (P < 0.001). Pre-pregnancy Body Mass Index (BMI) was higher in group A vs group B (28 ± 6 vs. 24 ± 7; P < 0.001). Conclusions: early and late preeclampsia appear to be different hemodynamic entities. Late preeclampsia appears to be more frequent in patients with high BMI and low TVR; earlier forms of preeclampsia appear to be more frequent in patient with low BMI, high TVR and and with bilateral notching of the uterine artery. This is in line with the theory of a maternal late preeclampsia favoured by obesity, and a placental early preeclampsia favoured by a defective trophoblast invasion. Objectives: To determine whether the human chorionic gonadotrophin (hCG) ratio at 48 hours (h), defined as the hCG 48 h/hCG 0 h, can be used to reduce follow up of pregnancies of unknown location (PULs). Methods: We review our database of PULs in order to evaluate the effectiveness of a new protocol in reducing follow up of PULs. In the original database 940 PULs were followed up until final diagnosis: failing PUL, viable and non-viable intra-uterine pregnancy (IUP),
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