Ein chiraler Komplex aus einem N,O‐Liganden und Cu(OAc)2 erwies sich als exzellenter Katalysator für die katalytische enantioselektive 1,3‐dipolare Cycloaddition von Azomethin‐Yliden an Alkylidenmalonate. Eine Serie hoch funktionalisierter exo‐Pyrrolidine wurde in hervorragenden Ausbeuten (80–99 %) und Enantioselektivitäten (91–99 % ee) erhalten (siehe Schema; M.S.: Molekularsieb).
Zebrafish Embryo Assay. -A synthetically versatile protocol for the stereospecific cyclization of homoallyl amine derivatives (I) to deliver cis-azetidines (III) and cis-or trans-pyrrolidine derivatives (V)-(IX) is developed. The selective access to these compounds is achieved via fine tuning of temperature and reaction sequence. Azetidine (IIIi) exhibits interesting effects in a zebrafish embryo developmental assay. -(FOSSEY*, J. S.; et al.; Org. Biomol. Chem. 11 (2013) 31, 5083-5093, http://dx.doi.org/10.1039/c3ob41007b ; Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK; Eng.) -S. Karsten 50-116
The ability to monitor analytes within physiological, environmental, and industrial scenarios is of prime importance. As recognition events occur on a molecular level, gathering and processing the information poses a fundamental challenge. Therefore, robust chemical molecular sensors, known as “chemosensors,” with the capacity to detect chosen molecules selectively and signal this presence continue to attract considerable attention. Real‐time monitoring of saccharides is of particular interest, such as
D
‐glucose in blood. Toward that end, the covalent coupling interaction between boronic acids and saccharides has been exploited with some success to monitor the presence of such saccharides. The boronic acid–and Lewis acid base interaction is also suitable for the capture and recognition of anions. Anions are involved in fundamental processes in all living things. Our aim as synthetic chemists is to mimic nature s level of sophistication in designing and producing chemosensors capable of determining the concentration of a target analyte (i.e., saccharides and anions) in any medium.
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