1 suggest that the use of folic acid antagonists in pregnant women increases the risk of oral clefts and cardiovascular and urinary tract defects in their infants. The possible role of trimethoprim in increasing the risk of malformations of the cardiovascular and urinary systems has practical implications. Trimethoprim is one of the most commonly prescribed drugs in the United States. Furthermore, it is commonly given in the early stages of pregnancy, often before women are aware that they are pregnant. In their report, Hernández-Díaz and colleagues group together data on trimethoprim, triamterene, and sulfasalazine. We wonder why the data on trimethoprim were not highlighted and reported separately, considering the widespread use of this drug.
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