Using a flow of 50 ml/s, FENO increases following admission for IV antibiotic treatment in children with CF but does not correlate with lung function. It is not a useful marker of lung diseases in CF, which has implications for clinical practice.
A NEW series of 1,8 naphthyridine derivatives with antibacterial properties has been synthesised recently at the Sterling-Winthrop Research Institute (Lesher et al., 1962). Extensive chemotherapeutic studies have revealed that one of these, l-ethyl-7-methyl-l,8-naphthyridine-4one-3-carboxylic acid (Negram or nalidixic acid), has a high order of activity against Gram-negative bacteria both in vitro and in vivo (Deitz, Froelich, and Bailey, personal communication). Toxicological, pharmacological, and biochemical investigations have established that the drug is safe for human clinical trials (McChesney et al., 1964), while administration to volunteers for up to six months has confirmed that the substance is generally well tolerated in daily doses of up to 8 g. per day (Stough, personal communication).Recently the results of a trial of the drug in hospital practice has been reported (Swinney and Lishman, 1963). In view of these good results and the overall promise of Negram, we have undertaken a trial of this drug in the treatment of urinary infections under conditions obtaining in general practice. It was hoped also that the investigation would reveal the pattern of urinary infection as seen in general practice in South-West London and Surrey during the summer of 1962.
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