The biogenesis of zearalenone or F-2 (2,4-dihydroxy-6-(10-hydroxy-6-oxo-trans-1-undecenyl) benzoic acid lactone) was examined. Of several possible precursors, acetate and malonate were incorporated most readily, and malonate was shown to inhibit incorporation from acetate. Zearalenone isolated from cultures of Fusarium roseum fed 1-14C-acetate was chemically degraded and the distribution of 14C examined. Both the kinetic and degradation studies suggest that zearalenone is derived from acetate through the polyketide pathway.
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