Summary: Serum uric acid levels measured by the phosphotungstic sodium cyanide method have been estimated in 60 patients suffering from a cerebrovascular incident. Patients with diseases known to predispose to hyperuricaemia were excluded. Twenty-five per cent. of patients with acute strokes had hyperuricaemia, and this did not appear to be a transitory phenomenon. These findings suggest that hyperuricaenia may be one of the factors in the pathogenesis of atheroma."La goutte est aux art6res ce que le rhumatisme est aux cceurs " (Huchard, 1899).
Department of Agricultural and Food Chemistry, The Queen's University of Belfast, Newforge Lane, Belfast, BT9 5PX, and Department of Agriculture, Northern Ireland
(Received 1 July 1977)
Before the onset of egg laying in the domestic fowl, there are increases in the lipid content of the plasma and liver (Chaikoff, Lorenz & Entenman, 1941; Heald & Badman, 1963). These changes are the result of oestrogen secretion by the ovary (Sturkie, 1965). Hepatic lipogenic enzymes also increase in activity during the onset of sexual maturity and their specific activities are greater in the laying hen than in the mature cockerel (Pearce, 1971); similar changes in the activities of hepatic lipogenic enzymes have been observed in oestrogen-treated immature pullets (Balnave & Pearce, 1974). The synthesis of yolk proteins in the liver is also induced by the administration of oestrogen to immature pullets and cockerels (Gruber, 1972). The action of oestrogen is antagonized by
Abstract.
Six synthetic C-terminal shortened fragments of the reduced and S-carbamidomethylated peptide corresponding to residues 177 to 191 of human growth hormone (Cam-hGH 177–191) were assayed for insulin antagonistic activity in vivo. Two of the peptides, CamhGH 177–191 and cam-hGH 177–191 were, in nanomolar quantities, both active in that they caused significant hyperglycaemia and insulin resistance in normal rats. The remaining peptides, hGH 177–180, Cam-hGH 177–185, Cam-hGH 177–187 and hGH 177–189 were all inactive even at up to one hundred times the dose employed for the active peptides. The results indicate that an insulin antagonistic core of hGH is contained within amino acid residues 178 to 190 inclusive.
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