gated over a period of 18 months. With 25 mg. of dipipanone given by the deep subcutaneous or intramuscular route, adequate relief of pain in labour was achieved in over 90 % of cases. Dipipanone was found to be a satisfactory adjunct to general anaesthesia. The dose initially required varied from 2.5 to 5 mg. according to the patient's age, weight, and physical condition. The total dose required for an operation of average duration was from 5 to 10 mg. An alternative technique for the maintenance of controlled respiration during thoracotomy is presented, using dipipanone in place of muscle relaxants. We wish to thank Mr. Kirwan Taylor for permission to conduct the trial of dipipanone in his maternity unit and to Sister Styles and her staff for their cooperation and help. We should also like to express our appreciation of the help we received from Sister Mathias, the senior theatre sister. We owe a special debt to Dr. G. Edwards for his encouragement and advice. " Pipadone " brand injection of dipipanone hydrochloride was kindly supplied by Burroughs Wellcome and Co.

THIOPENTONE was introduced to clinical anaesthesia by Lundy in 1934 and the first reports of its use appeared in the following year (Lundy, 1935; Lundy and Tovell, 1935). Since then, thiopentone has almost entirely superseded other intravenous agents and has become the standard agent for inducing anaesthesia. It is not, however, without certain dangers. The main disadvantages are the occasional occurrence of laryngeal spasm (Lee, 1953; Dundee, 1956) and the ease with which respiratory depression due to overdosage can be produced. Another objection to thiopentone is that, following induction and a brief period of anaesthesia, the patients often have a relatively prolonged period when they are drowsy and confused and in a state described by Lundy (1935) as resembling alcoholic inebriation. Research workers have been constantly seeking other similar drugs which.would show a shorter recovery period with less postanaesthetic confusion, and buthalitone was introduced as such a drug. Claims have also been made that the incidence of respiratory depression and vagotonic effects is less with this drug than with thiopentone (Davidson and Love, 1956). Buthalitone was first prepared by Miller et al. (1936) but it was not used clinically until 1954 when Weese and Koss reported on a clinical trial of 350 cases. This has been followed by numerous reports of other clinical trials in which this drug has been used (

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BRuTISH 1095 MEDIrAUL JOURNAL. gated over a period of 18 months. With 25 mg. of dipipanone given by the deep subcutaneous or intramuscular route, adequate relief of pain in labour was achieved in over 90 % of cases. Dipipanone was found to be a satisfactory adjunct to general anaesthesia. The dose initially required varied from 2.5 to 5 mg. according to the patient's age, weight, and physical condition. The total dose required for an operation of average duration was from 5 to 10 mg.An alternative technique for the maintenance of controlled respiration during thoracotomy is presented, using dipipanone in place of muscle relaxants.We wish to thank Mr. Kirwan Taylor for permission to conduct the trial of dipipanone in his maternity unit and to Sister Styles and her staff for their co-operation and help. We should also like to express our appreciation of the help we received from Sister Mathias, the senior theatre sister. We owe a special debt to Dr. G. Edwards for his encouragement and advice. " Pipadone " brand injection of dipipanone hydrochloride was kindly supplied by Burroughs Wellcome and Co.

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