The less frequent use of surgical prostatectomy at our institution has produced marked decline in detection of T1a-b cancer. If representative of national trends this experience suggests that many men with obstructive voiding symptoms and T1a-b cancer will remain undiagnosed and that periodic monitoring to identify unsuspected cancer is important in men who are treated with medical or minimally invasive therapies for BPH. Decline in detection of T1a-b cancer may also confound the accuracy of projected incidence rates of local prostate cancer in the United States.
METHODS.The authors conducted a prospective, hospital-based study of gonadal androgen ablation with deferred antiandrogen therapy in 103 men with prostate
RESULTS.Each patient experienced regression of the primary tumor, and none 2 Department of Pathology, University of Missisexperienced significant morbidity from the primary tumor during the study period. sippi School of Medicine, Jackson, Mississippi.The projected 5-year cause specific, metastasis free, PSA disease free (no PSA elevation ú 1.0 ng/mL after the beginning of antiandrogen therapy), and all-cause survival rates were 84%, 84%, 68%, and 58%, respectively.
CONCLUSIONS.Primary hormone therapy is a reasonable treatment option for locally advanced prostate carcinoma in elderly men or in men with significant comorbid disease who request therapeutic intervention.
METHODS.The authors conducted a prospective, hospital-based study of gonadal androgen ablation with deferred antiandrogen therapy in 103 men with prostate
RESULTS.Each patient experienced regression of the primary tumor, and none 2 Department of Pathology, University of Missisexperienced significant morbidity from the primary tumor during the study period. sippi School of Medicine, Jackson, Mississippi.The projected 5-year cause specific, metastasis free, PSA disease free (no PSA elevation ú 1.0 ng/mL after the beginning of antiandrogen therapy), and all-cause survival rates were 84%, 84%, 68%, and 58%, respectively.
CONCLUSIONS.Primary hormone therapy is a reasonable treatment option for locally advanced prostate carcinoma in elderly men or in men with significant comorbid disease who request therapeutic intervention.
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