Triamcinolone and triamcinolone 16a,2 1-diacetate have been characterized by ultraviolet absorption spectra, infrared absorption spectra, absorption spectra in sulfuric acid, polarogra hy, reduction of tetrazolium blue, and by Porter-Silber chromogens. The use of agsorption spectra, polarography, and colorimetry for quantitative determination of bulk triamcinolone and of triamcinolone in tablets is discussed.Some new chemistry of 16a-hydroxylated steroids is reviewed. RIAMCINOLONE (9a -fluoro -11/3,16a,lia,21tetrahydroxy-l,4-pregnadiene-3,20-dione) is a new potent corticosteroid of clinical importance (1-3). Triamcinolone is currently marketed in this country as the alcohol, although the IGa,21diacetate has been tested clinically (4). Characterization of the hormone has been limited to brief accounts in the chemical journals (5-i) and in the patent literature (8). A more detailed characterization of both triamcinolone and triamcinolone diacetate is the subject of this report. in the preparation of triamcinolone and triamcinolone diacetate standards. Ultraviolet absorption spectra were obtained under the direction of Mr. Walter Muller, infrared spectra were kindly supplied by Mr. William Fulmor.
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