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Vol. 70 globulins are precipitated directly from the blood serum for such later purification or separation into sub-fractions as may be desired. The important differences in conditions of separation are the immediate adjustment of the serum to pH 7.7 and the use of a considerably greater dilution of the serum as fractionation begins. The new conditions serve several very useful purposes. The sharpness of cleavage between ß-and -globulins is markedly increased. The removal of the gamma globulin is simple and direct. Tendencies toward denaturation are reduced. Actual yields of -globulin are now in excess of 85%.As a result of the work described in this report and in the companion article5 6 it may be predicted that practical and economical ethanol fractionation methods for the removal of antibody from hyperimmune sera will be soon in operation.

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The Oxidation of Free Methyl Radicals 15 pendence suggest that the charge of the product ion of equation 4 is more negative than -1. Since TaXeis stable over a considerably larger HF concentration range than NbXs~and since the high reactivity of the latter ion was attributed to one oxide ion in the complex,1 2 it appears that TaX3ĩ s not oxygenated. Thus in reaction (4) probably only chloride ions could be liberated. The HC1 dependence of is remarkably small and the sum of chloride and oxonium ions liberated is therefore probably not larger than one. Hence, since = 2, the most probable formula of the product tantalum complex becomes HTaX6F3-2 and equation ( 4) reduces to TaXEF-+ 2HF + H20 HTaXsFr! + H30+ (7)The corresponding molarity constants Kv> be-come 2.5 and 0.53 for 9 M HC1 and 3 M HC1, respectively.Summary 1. The anion exchange behavior of tantalum was studied for a number of HC1-HF mixtures. It was found to adsorb very strongly under most conditions, even in 9 M HC1.2. The species TaX6F~a nd HTaX6F3~2 have been tentatively identified and the molarity constants for the probable reaction TaX5F-+ 2HF + H20 ^Z±i HTaX6F3-2 + HsO + were estimated to be 2.5 and 0.53 for 9 M HC1 and 3 M HC1 solutions, respectively.Oak Ridge, Tennessee

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