A distinctive, benign, spindle cell tumor of the breast is described. Three patients were men, the fourth a woman. Histologically, each tumor displayed islands of spindle or stellate cells embedded in a collagenous matrix. Within the female breast, the lesion was within the stroma, displacing but not including the epithelial elements. Ultrastructural study of two tumors revealed diverse populations composed of fibroblasts, myofibroblasts, smooth muscle cells, and undifferentiated mesenchymal cells. The relationship of these tumors to spindle cell lipomas is discussed. The lesions have all been clinically benign, and their recognition as such is important. Cancer 48:1615-1622, 1981. HIS REPORT will document a distinctive type of T breast tumor. The lesion is histologically characteristic and is remarkable in that in three of the four cases presented, the patients were men (Table 1). Case Reports Case I The patient, a 46-year-old man, presented with a five-week history of a swelling in the right breast. He had a firm 2 x 3 cm nodule 2 cm below the right nipple. The mass was excised. The histologic features are illustrated in Figures 1 and 2. Aggregates of spindle shaped or stellate cells were embedded in a dense collagenous matrix. Nuclei stained darkly and were conspicuous. While the nuclei vaned somewhat in size and shape, pleomorphism was not pronounced. Mitoses were not seen. Cytoplasm was generally scanty although a few plump cells displayed more liberal amounts. Cell margins were often ill defined, especially where the cells were crowded together. Fine collagen fibrils were visible within the cell groups. A few mature fat cells were scattered throughout the lesion. The patient was last seen by the surgeon one year after the
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