Diabetic myopathy may occur more frequently in patients with type 2 diabetes than previously reported. In this population, T2-weighted and contrast-enhanced images have similar findings, and the increased coexistence of nephropathy makes administration of gadolinium-based contrast agents ill-advised. With a typical clinical presentation and MRI findings, a confident diagnosis can be made, and potentially harmful biopsy is avoided. Diabetic myopathy encompasses a spectrum of diseases, including muscle inflammation, ischemia, hemorrhage, infarction, necrosis, fibrosis, and fatty atrophy. It is usually seen with long-standing, poorly controlled diabetes.
The following case report features a middle-aged female patient, previously diagnosed with Cowden syndrome, who presented to the hospital with symptoms of headaches and changes in vision that began with no apparent cause and persisted for almost a month. MRI of the head confirmed a diagnosis of dysplastic cerebellar gangliocytoma, also known as Lhermitte-Duclos disease. This cerebellar tumor, while extremely rare in incidence, is classified as the most common type of brain lesion in adult patients with Cowden syndrome. This report will also include a comprehensive literature review of Cowden syndrome and Lhermitte-Duclos disease, with greater emphasis on the radiologic characteristics of Lhermitte-Duclos disease.
Neuroradiology:Radiographic Findings of Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease) in a Woman with Cowden Syndrome: A Case Study and Literature Review Joo et al.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.