Postoperative clinical outcome scores were generally good to excellent following arthroscopic remplissage. No studies indicated a significant loss of shoulder motion following the procedure. The failure rate following Hill-Sachs remplissage compared favorably with previously published rates for patients without clinically important Hill-Sachs lesions who underwent arthroscopic Bankart repair alone. The overall complication rate across the studies was low, further supporting the use of this technique along with Bankart repair in the treatment of glenohumeral instability with a concurrent osseous defect of the humeral head.

The presence of a retear negatively affected the clinical outcomes following rotator cuff repair. This finding refutes the widely held concept that patients typically do well regardless of the repair integrity following rotator cuff repair. In patients with a retear, nonanatomic factors including younger age, lower education level, and a Workers' Compensation claim were associated with poorer outcomes.

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➢ Navigation provides information about patient anatomy and the relative positioning of the implants to guide the surgeon.➢ Some systems use a robotic arm that assists with specific parts of the procedure on the basis of anatomical information provided to the navigation system. Currently, all total hip arthroplasty robotic systems require preoperative imaging.➢ Imageless systems rely only on intraoperative landmarks identified by the surgeon and provide feedback about limb alignment and component positioning.➢ The primary benefits of navigation are a reduction in outliers during acetabular cup positioning and improved accuracy when quantifying limb-length and offset measurements. It remains to be seen whether these benefits translate into meaningful improvements in clinical outcomes.

Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by insulin deficiency, and patients with diabetes have an increased risk of bone fracture and significantly impaired fracture healing. Proinflammatory cytokine tumor necrosis factor‐alpha is significantly upregulated in diabetic fractures and is believed to underlie delayed fracture healing commonly observed in diabetes. Our previous genetic screen for the binding partners of progranulin (PGRN), a growth factor‐like molecule that induces chondrogenesis, led to the identification of tumor necrosis factor receptors (TNFRs) as the PGRN‐binding receptors. In this study, we employed several in vivo models to ascertain whether PGRN has therapeutic effects in diabetic fracture healing. Here, we report that deletion of PGRN significantly delayed bone fracture healing and aggravated inflammation in the fracture models of mice with T1DM. In contrast, recombinant PGRN effectively promoted diabetic fracture healing by inhibiting inflammation and enhancing chondrogenesis. In addition, both TNFR1 proinflammatory and TNFR2 anti‐inflammatory signaling pathways are involved in PGRN‐stimulated diabetic fracture healing. Collectively, these findings illuminate a novel understanding concerning the role of PGRN in diabetic fracture healing and may have an application in the development of novel therapeutic intervention strategies for diabetic and other types of impaired fracture healing.

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The purpose of this study was to examine the influence of topical vancomycin on cell migration and survival of tissue healing cells. Human osteoblasts, myoblasts and fibroblasts were exposed to vancomycin at concentrations of 1, 3, 6, or 12 mg/cm for either a 1-h or 48-h (continuous) duration. Continuous exposure to all vancomycin concentrations significantly reduced cell survival (<22% cells survived) and migration in osteoblasts and myoblasts (P < 0.001). 1-h vancomycin exposure reduced osteoblast and myoblast survival and migration only at 12 mg/cm (P < 0.001). Further studies are warranted to optimize the dosage of intrawound vancomycin.