Kolonnen mit strukturierten Packungen finden eine weite Verbreitung in Destillations‐ und Absorptionsprozessen der verfahrenstechnischen Industrie. Für eine potenzielle neue Auslegungsmethode für Packungskolonnen mit strukturierten Packungen auf Basis von miniaturisierten Messzellen werden das Design und die Evaluierung zweier entwickelter Messzellen zur Bestimmung charakteristischer Kenngrößen der Hydrodynamik in Packungskolonnen vorgestellt. Ergebnisse zum Flüssigkeits‐Holdup aus beiden Messzellen werden mit etablierten Berechnungsmodellen und eigenen Validierungsmessungen in einer Technikumskolonne verglichen.
Background: Calibration of dynamic models in biotechnology is challenging. Kinetic models are usually complex and differential equations are highly coupled involving a large number of parameters. In addition, available measurements are scarce and infrequent, and some key variables are often nonmeasurable. Therefore, effective optimization and statistical analysis methods are crucial to achieve meaningful results. In this research, we apply a metaheuristic scatter search algorithm to calibrate a solid substrate cultivation model. Results: Even though scatter search has shown to be effective for calibrating difficult nonlinear models, we show here that a posteriori analysis can significantly improve the accuracy and reliability of the estimation. Conclusions: Sensibility and correlation analysis helped us detect reliability problems and provided suggestions to improve the design of future experiments.
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