Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria.
Burkholderia pseudomallei
clinical isolates are usually highly cefiderocol susceptible, with
in vitro
resistance found in a few isolates. Resistance in clinical
B. pseudomallei
isolates from Australia is caused by a hitherto uncharacterized mechanism.
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