Cardiac electrophysiology and cardiac mechanics both depend on the average cardiomyocyte long‐axis orientation. In the realm of personalized medicine, knowledge of the patient‐specific changes in cardiac microstructure plays a crucial role. Patient‐specific computational modelling has emerged as a tool to better understand disease progression. In vivo cardiac diffusion tensor imaging (cDTI) is a vital tool to non‐destructively measure the average cardiomyocyte long‐axis orientation in the heart. However, cDTI suffers from long scan times, rendering volumetric, high‐resolution acquisitions challenging. Consequently, interpolation techniques are needed to populate bio‐mechanical models with patient‐specific average cardiomyocyte long‐axis orientations. In this work, we compare five interpolation techniques applied to in vivo and ex vivo porcine input data. We compare two tensor interpolation approaches, one rule‐based approximation, and two data‐driven, low‐rank models. We demonstrate the advantage of tensor interpolation techniques, resulting in lower interpolation errors than do low‐rank models and rule‐based methods adapted to cDTI data. In an ex vivo comparison, we study the influence of three imaging parameters that can be traded off against acquisition time: in‐plane resolution, signal to noise ratio, and number of acquired short‐axis imaging slices.
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