Many domains of science have developed complex simulations to describe phenomena of interest. While these simulations provide high-fidelity models, they are poorly suited for inference and lead to challenging inverse problems. We review the rapidly developing field of simulation-based inference and identify the forces giving additional momentum to the field. Finally, we describe how the frontier is expanding so that a broad audience can appreciate the profound influence these developments may have on science.

We develop, discuss, and compare several inference techniques to constrain theory parameters in collider experiments. By harnessing the latent-space structure of particle physics processes, we extract extra information from the simulator. This augmented data can be used to train neural networks that precisely estimate the likelihood ratio. The new methods scale well to many observables and high-dimensional parameter spaces, do not require any approximations of the parton shower and detector response, and can be evaluated in microseconds. Using weak-boson-fusion Higgs production as an example process, we compare the performance of several techniques. The best results are found for likelihood ratio estimators trained with extra information about the score, the gradient of the log likelihood function with respect to the theory parameters. The score also provides sufficient statistics that contain all the information needed for inference in the neighborhood of the Standard Model. These methods enable us to put significantly stronger bounds on effective dimension-six operators than the traditional approach based on histograms. They also outperform generic machine learning methods that do not make use of the particle physics structure, demonstrating their potential to substantially improve the new physics reach of the LHC legacy results. CONTENTS1 Exceptions can arise for instance when particle masses or widths depend on the parameters of interest. But in an EFT setting one can expand these quantities in 1/Λ, restoring the factorization.

Simulators often provide the best description of real-world phenomena. However, they also lead to challenging inverse problems because the density they implicitly define is often intractable. We present a new suite of simulation-based inference techniques that go beyond the traditional Approximate Bayesian Computation approach, which struggles in a high-dimensional setting, and extend methods that use surrogate models based on neural networks. We show that additional information, such as the joint likelihood ratio and the joint score, can often be extracted from simulators and used to augment the training data for these surrogate models. Finally, we demonstrate that these new techniques are more sample efficient and provide higherfidelity inference than traditional methods.

We present powerful new analysis techniques to constrain effective field theories at the LHC. By leveraging the structure of particle physics processes, we extract extra information from Monte Carlo simulations, which can be used to train neural network models that estimate the likelihood ratio. These methods scale well to processes with many observables and theory parameters, do not require any approximations of the parton shower or detector response, and can be evaluated in microseconds. We show that they allow us to put significantly stronger bounds on dimension-six operators than existing methods, demonstrating their potential to improve the precision of the LHC legacy constraints.

The legacy measurements of the LHC will require analyzing high-dimensional event data for subtle kinematic signatures, which is challenging for established analysis methods. Recently, a powerful family of multivariate inference techniques that leverage both matrix element information and machine learning has been developed. This approach neither requires the reduction of high-dimensional data to summary statistics nor any simplifications to the underlying physics or detector response. In this paper we introduce MadMiner, a Python module that streamlines the steps involved in this procedure. Wrapping around MadGraph5_aMC and Pythia 8, it supports almost any physics process and model. To aid phenomenological studies, the tool also wraps around Delphes 3, though it is extendable to a full Geant4based detector simulation. We demonstrate the use of MadMiner in an example analysis of dimension-six operators in ttH production, finding that the new techniques substantially increase the sensitivity to new physics.