Background Basal cell carcinoma (BCC) is the most common skin cancer. Incidence is largely unknown because of incomplete, or lack of, registration in most countries. Objectives To assess current incidence rates and recent trends for BCC in the Swedish population. Methods Patient-and tumour-related features of all histologically confirmed BCC tumours diagnosed in Sweden from 2004 to 2017 were extracted from the population-based Swedish BCC Registry. Incidence rates were standardized to the 2013 European Standard Population and trends were analysed using Poisson regression models. ResultsThe age-standardized person-based incidence rate of BCC in Sweden was 405 per 100 000 in 2017, rising from 308 per 100 000 in 2004, corresponding to an annual relative increase of 1Á8% (women, 2Á1%; men, 1Á4%). Incidence was highest in elderly people and the most common tumour site was the head and neck. In 2017, the most common BCC subtypes were nodular and micronodular/infiltrative BCC (each 31%). Incidence of aggressive BCC subtypes increased faster than other subtypes. Conclusions BCC incidence rates in Sweden are relatively high and increasing. The increasing trends were more pronounced in women and for aggressive BCC subtypes.

Background Basal cell carcinoma (BCC) is the most common skin cancer form, and one first-line treatment is surgical excision. Complete excision is vital to minimize risk of recurrence. Studies on occurrence of incomplete excisions have given diverse results and seldom include large populations from a dermatological setting. Objectives The rate of positive surgical margins in primary surgery of BCC at a tertiary dermatology clinic is studied. Factors associated with an incomplete primary excision are analysed. Methods Patients scheduled for standard excision, without perioperative margin control, of BCC during the years 2008-2015 were prospectively enrolled in the study. Tumour-specific factors, including histopathologic subtype, as well as postoperative outcome were registered. Incomplete excisions were analysed in relation to patient-and tumour-related factors. Results In total, 4.6% of 3911 BCC tumours were incompletely excised. The rate of incomplete excisions was higher for facial tumours and among tumours with an aggressive histological subtype. Morpheiform BCC on the nose or ear had the highest rate of an incomplete excision, 61.5% and 50%, respectively. Conclusions Most BCCs, irrespective of subtype, were completely excised during the primary excision. Tumour sites nose and ears were associated with the highest rate of positive primary surgical margins, especially for infiltrative or morpheiform BCCs. Surgery with perioperative examination of margins is strongly recommended for these tumours.

Prognosis of aphasia in stroke patients early after iv thrombolysis.Kremer, Christine; Perren, Fabienne; Kappelin, Johan; Selariu, Eufrozina; Abul-Kasim, Kasim Link to publication Citation for published version (APA): Kremer, C., Perren, F., Kappelin, J., Selariu, E., & Abul-Kasim, K. (2013). Prognosis of aphasia in stroke patients early after iv thrombolysis. Clinical Neurology and Neurosurgery, 115(3), 289-292. DOI: 10.1016289-292. DOI: 10. /j.clineuro.2012 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Prognosis of Aphasia in Stroke Patients early after iv Thrombolysis ABSTRACTObjective -Intravenous rt-PA (iv) thrombolysis is given more deliberately to stroke patients presenting with aphasia. Early outcome data is lacking. Aim of this study was to determine early benefit from rt-PA in patients with aphasia. Methods -Data of stroke patients treated by iv thrombolysis 2002-2008 was scrutinized for the presence of aphasia defined as ≥1 point for aphasia on the National Institute of Health Stroke Scale (NIHSS). Improvement was defined as a gain of ≥1 point within 24 hours. Cranial computed tomography (CT) scans were evaluated regarding early ischemic changes (EICs), infarct volume and localization Results -50 patients with aphasia were included. 16 (32%) of patients improved (4 (36%) minor, 7 (41%) moderate, 5 (23%) major stroke patients), while 44 (62 %) remained unchanged. Of 28 patients with EICs, 10 (36 %) improved compared to 7 out of 22 (32%) patients without (p=0.773). Aphasia outcome was significantly associated with infarct volume at admission and at 24 hours (Kruskal Wallis, p=0.033, p=<0,001, respectively). Conclusion -EICs are not predictive of aphasia outcome and patients with improvement showed smaller infarct volumes. 32% improved in their aphasia within 24 hours, probably due to early reperfusion, while 62% remained unchanged. This might justify a closer follow-up of aphasia in stroke patients at the acute stage.