The reaction of elemental fluorine with phenyl derivatives of tin, lead, germanium, silicon, mercury, and thallium has been studied with the aim of developing a general method for labelling aromatic compounds with radioactive 18F. Rapid synthesis of fluorobenzene was achieved in varying chemical yields up to 70%, depending largely upon the metal substrate used, with aryl–tin compounds giving the highest yields. Radiochemical yields are also given for the synthesis of 18F-fluorobenzene from the cleavage of aryl–tin bonds with 18F-F2.
De,u(~rtit~e/~t of Clle~?!i~t~:\., The L'ni~,er.sit?. oj'Bt.iti~h Col~rn~bin, Vu~~c.orr\-ei. 8, British Col~rr?lbia Received July 13. 1972.The configuration (D or L) of a sugar may be determined conveniently by c i r c~~l a r dichroism measurements at 213 nm on alditol acetates, or their niethylared derivatives, where the acetoxy group acts as a chron~ophcre. Only milligram quantities of niaterial are required and the method is well suited to a n a l y~-Ing fractions obtained by gas-liquid chromatography. Structural information which ]nay be derived from he c.d. spectra is briefly discussed.La configtlration ( D or L) d'un sucre peut Ctre etabiie par le dicl-iroisme circulaire 8 213 nm soit des alditol acetates soit de l e~i r de~ives methyles, oh le gro~ipelnent acetate jcue le i6le de chromophore. O n ne necessite que de tres petites y~~a n t i t e s de substance et la n~ethode s'adapte tres bien a l'analyse des fractions obten~ies par chromatographie en phase gaseuse. On discute brievement des renseignn~ents structuraux que fournissent les spectres d.c.( a n . J . Cheni.. 51. 32-1 (1971)
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