Adult zebrafish pairs were exposed to sub-lethal concentrations of BaCl2 for 21 days, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic-pituitary-gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BaCl2. Egg production was significantly decreased, and parental exposure to BaCl2 resulted in lesser rates of hatching. In males, exposure to BaCl2 resulted in greater concentrations of E2 along with greater mRNA expression of cyp19a. The results demonstrated that BaCl2 could modulate gene transcriptions and hormone production of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring.
In parallel-beam tomography, the virtual alignment method plays an important role in obtaining an ideally aligned reconstruction of a rigid specimen. Furthermore, the method has been developed for elastic specimens with specific motions such as periodic motion, regular expansion or contraction, and elliptical expansion or contraction to obtain a sinogram with an ideal sinogram pattern by transforming an elastic-type projection image set into a rigid-type projection image set satisfying the Helgason-Ludwig consistency condition. In this article, we present a method to convert a combined elastic specimen to a rigid specimen using the virtual multi-alignment method that allows us to obtain an ideally multi-aligned reconstruction of a combined elastic specimen.
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