We describe 2 patients who developed rhabdomyolysis due to dengue virus infection. The first patient recovered with no sequelae, but the second developed multiple organ failure and died. Rhabdomyolysis is not well described as a complication of dengue virus infection and is probably underrecognized. All patients with severe dengue virus infection should undergo urinalysis, and serum creatinine kinase levels should be measured if urinalysis reveals heme.
*awetj@lanl.govOne-dimensional radiation-hydrodynamic simulations are performed to develop insight into the scaling of stagnation pressure with initial conditions of an imploding spherical plasma shell or "liner." Simulations reveal the evolution of high-Mach-number (M), annular, spherical plasma flows during convergence, stagnation, shock formation, and disassembly, and indicate that cmand µs-scale plasmas with peak pressures near 1 Mbar can be generated by liners with initial kinetic energy of several hundred kilo-joules. It is shown that radiation transport and thermal conduction must be included to avoid non-physical plasma temperatures at the origin which artificially limit liner convergence and thus the peak stagnation pressure. Scalings of the stagnated plasma lifetime (τ stag ) and average stagnation pressure (P stag , the pressure at the origin, is also found for a wide range of liner-plasma initial conditions.
BackgroundMicroRNAs are key transcriptional and network regulators previously associated with asthma susceptibility. However, their role in relation to asthma severity has not been delineated.ObjectiveWe hypothesized that circulating microRNAs could serve as biomarkers of changes in lung function in asthma patients.MethodsWe isolated microRNAs from serum samples obtained at randomization for 160 participants of the Childhood Asthma Management Program. Using a TaqMan microRNA array containing 754 microRNA primers, we tested for the presence of known asthma microRNAs, and assessed the association of the individual microRNAs with lung function as measured by FEV1/FVC, FEV1% and FVC%. We further tested the subset of FEV1/FVC microRNAs for sex-specific and lung developmental associations.ResultsOf the 108 well-detected circulating microRNAs, 74 (68.5%) had previously been linked to asthma susceptibility. We found 22 (20.3%), 4 (3.7%) and 8 (7.4%) microRNAs to be associated with FEV1/FVC, FEV1% and FVC%, respectively. 8 (of 22) FEV1/FVC, 3 (of 4) FEV1% and 1 (of 8) FVC% microRNAs had functionally validated target genes that have been linked via genome wide association studies to asthma and FEV1 change. Among the 22 FEV1/FVC microRNAs, 9 (40.9%) remain associated with FEV1/FVC in boys alone in a sex-stratified analysis (compared with 3 FEV1/FVC microRNAs in girls alone), 7 (31.8%) were associated with fetal lung development, and 3 (13.6%) in both. Ontology analyses revealed enrichment for pathways integral to asthma, including PPAR signaling, G-protein coupled signaling, actin and myosin binding, and respiratory system development.ConclusionsCirculating microRNAs reflect asthma biology and are associated with lung function differences in asthmatics. They may represent biomarkers of asthma severity.
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