Substantial clinical interest has developed in the use of in situ curing acrylic polymer for stabilization of joint prostheses. This study used canines to determine the local-tissue effects from heat and unreacted monomer and the distal effects due to monomer leakage into the venous circulation. These were also studied in humans. The results show monomer levels as high as 1.3 mg % in the central venous system. In canines, levels of 5 mg % caused local pulmonary hemorrhage; however, no long-term morbidity was found at levels as high as 50 mg %. Thermal trauma is substantial at the implant/tissue interface. Fibrous tissue sequestration occurs and may lessen the long-term prosthesis stabilization. The mechanical properties of the polymer are substantially compromised by inclusions of blood at implantation.
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