The facile self‐assembly of six pyrogallol[4]arene molecules leads to a globular truncated octahedron, which encapsulates a guest cluster consisting of ethyl acetate and water molecules (see scheme). The interactions between host capsules can be controlled by derivatization of the exterior surface of the capsule.
The single step direct synthesis of pyrogallol[4]arene via a solvent free protocol yields the pure product as a self-assembled nano-capsule, comprised of six macrocyclic building blocks.
Under various conditions, water molecules dramatically affect a number of solid-state C-alkylpyrogallol[4]arene assemblies. In the absence of water, hydrogen-bonded hexameric capsules are formed for the C-butyl, pentyl, hexyl, and heptyl pyrogallol[4]arenes. Introduction of water to acetonitrile solutions containing C-propyl-C-octylpyrogallol[4]arenes resulted in the formation of markedly different bilayer structures and the structural identification of two new dimer-type motifs.
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