Background By end December of 2021, COVID-19 has infected around 276 million individuals and caused over 5 million deaths worldwide. Infection results in dysregulated systemic inflammation, multi-organ dysfunction, and critical illness. Cells of the central nervous system are also affected, triggering an uncontrolled neuroinflammatory response. Low doses of glucocorticoids, administered orally or intravenously, reduce mortality among moderate and severe COVID-19 patients. However, low doses administered by these routes do not reach therapeutic levels in the CNS. In contrast, intranasally administered dexamethasone can result in therapeutic doses in the CNS even at low doses. Methods This is an approved open-label, multicenter, randomized controlled trial to compare the effectiveness of intranasal versus intravenous dexamethasone administered in low doses to moderate and severe COVID-19 adult patients. The protocol is conducted in five health institutions in Mexico City. A total of 120 patients will be randomized into two groups (intravenous vs. intranasal) at a 1:1 ratio. Both groups will be treated with the corresponding dexamethasone scheme for 10 days. The primary outcome of the study will be clinical improvement, defined as a statistically significant reduction in the NEWS-2 score of patients with intranasal versus intravenous dexamethasone administration. The secondary outcome will be the reduction in mortality during hospitalization. Conclusions This protocol is currently in progress to improve the efficacy of the standard therapeutic dexamethasone regimen for moderate and severe COVID-19 patients. Trial registration ClinicalTrials.govNCT04513184. Registered November 12, 2020. Approved by La Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) with identification number DI/20/407/04/36. People are currently being recruited. Graphical abstract
In response to the remote learning and teaching setup in science due to the COVID-19 pandemic, a lab at-home experiment was conducted where various plant materials were prepared and used as natural acid-base indicators for various household substances. The experiment is designed for the students to apply the fundamentals of intensive laboratory for science education: laboratory safety, laboratory apparatus, laboratory techniques, data documentation, and lab report writing. Presented herein are the results obtained during the experiments conducted at home that focused on the application of various plant extracts as natural indicator. Observable color changes showed that the tested plant extracts responded to the acidity and alkalinity of the various household substances. The science behind the color changes is attributed to the presence of various phytochemicals that change colors when protonated and deprotonated. The potential of the results obtained in the experiments is very promising as it can be further developed and optimized to an analytical procedure that can be applied in testing of acidity and alkalinity in various applications such as food safety and quality, environmental monitoring, materials testing, pharmaceutical analysis, and clinical diagnostics. Moreover, the experiment explored here presented lab teaching strategies that can be applied in the remote learning setup: formulate and design a home-based laboratory experiment that will cover the underlying scientific theories and skills and provide the students the opportunity to explore, improvise, apply, and present information that will holistically develop them as science educators for their current and prospective students.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.