An original approach for the synthesis from PGA2 of C-10 substituted PGE2 analogues is reported. A remarkable regio- and cyclo-selective Baeyer–Villiger reaction is described.
Die photochemische [2 + 2]‐Cycloaddition der PGAz‐Ester (I) mit Vinylacetat führt zu den Cycloaddukten (II), von denen (IIb) nach Acetatspaltung zu den stereoisomeren Diketosilylethern (III) und (IV) oxidiert wird.
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