A biomimetic, ion-regulated molecular receptor was synthesized via the Weak-Link Approach (WLA). This structure features both a calix[4]arene moiety which serves as a molecular recognition unit and an activity regulator composed of hemilabile phosphine alkyl thioether ligands (P,S) chelated to a Pt(II) center. The host-guest properties of the ion-regulated receptor were found to be highly dependent upon the coordination of the Pt(II) center, which is controlled through the reversible coordination of small molecule effectors. The environment at the regulatory site dictates the charge and the structural conformation of the entire assembly resulting in three accessible binding configurations: one closed, inactive state and two open, active states. One of the active states, the semiopen state, recognizes a neutral guest molecule, while the other, the fully open state, recognizes a cationic guest molecule. Job plots and (1)H NMR spectroscopy titrations were used to study the formation of these inclusion complexes, the receptor binding modes, and the receptor binding affinities (Ka) in solution. Single crystal X-ray diffraction studies provided insight into the solid-state structures of the receptor when complexed with each guest molecule. The dipole moments and electrostatic potential maps of the structures were generated via DFT calculations at the B97D/LANL2DZ level of theory. Finally, we describe the reversible capture and release of guests by switching the receptor between the closed and semiopen configurations via elemental anion and small molecule effectors.

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The H-acid dye intermediate was successfully attached to the SBA-15 mesoporous silica surface in a two-step modification process. Synthesized materials were characterized using several techniques including Fourier transform infrared spectroscopy, N2 adsorption−desorption measurements, small-angle X-ray scattering, transmission electron microscopy, and thermogravimetric analysis. The fluorescent sensing properties were examined in the final product toward several metal ions and showed high selectivity for Hg 2+ . Computational studies were performed in order to obtain a detailed electronic description of the quenching mechanism of H-acid fluorescence by Hg 2+ as well as studying the structure and bonding in the [H-acid]Hg 2+ complex.

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