Abstr act. Managing variability is a challenging issue in software-product-line engineering. A key part of variability management is the ability to express explicitly the relationship between variability models (expressing the variability in the problem space, for example using feature models) and other artefacts of the product line, for example, requirements models and architecture models. Once these relations have been made explicit, they can be used for a number of purposes, most importantly for product derivation, but also for the generation of trace links or for checking the consistency of a product-line architecture. This paper bootstraps techniques from product-line engineering to produce a family of languages for variability management for easing the creation of new members of the family of languages. We show that developing such language families is feasible and demonstrate the flexibility of our language family by applying it to the development of two variability-management languages.

SYNOPSISFrontalis EMG biofeedback and diazepam treatments were compared in tension headache patients; headache scores (intensity and frequency) and frontalis EMG were used as control parameters. The study, conducted in a double blind manner, was split in three equal observation periods (4 weeks): baseline, treatment and follow-up. Four patient groups were chosen, two of which received placebo treatment. In both true conditions, biofeedback and diazepam, treatment effects differentiated from placebo groups; with diazepam the strongest results upon headache and frontalis EMG were observed during treatment, which, however, were lost at the follow-up period; biofeedback although with weaker effects during treatment showed, at follow-up, a long lasting reduction of headache scores even when frontalis activity reached baseline levels; in the false biofeedback group some decrease of EMG activity during treatment and of headache intensity at follow-up were also observed. The data suggest that biofeedback is a complex learning situation, where several uncompletely known factors are possibly at work; it also raises the possibility of a complex relation between frontalis muscular activity and headache since a simple linear relation of both variables was not observed. (Headache 22:216-220, 1982)

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Mode-directed tabling is an extension to the tabling technique that supports the definition of modes for specifying how answers are inserted into the table space. In this paper, we focus our discussion on the efficient support for mode-directed tabling in the YapTab tabling system, which uses tries to implement the table space. We discuss 7 different modes and explain how we have extended and optimized YapTab's table space organization to provide engine support for them. Experimental results, in the context of benchmarks taking advantage of mode-directed tabling, show that our implementation compares favorably with the B-Prolog and XSB state-of-the-art tabling systems.

Disseminated intravascular coagulation (DIC) is the most frequent coagulation disorder associated with metastatic prostate adenocarcinoma. However, DIC with enhanced fibrinolysis as an initial presentation of prostate cancer is extremely rare. The appropriate treatment to control bleeding in these situations is challenging, controversial, and based on isolated case reports in the literature. A 66-year-old male presented at the emergency department with acute severe spontaneous ecchymoses localized to the limbs, laterocervical hematoma, and hemothorax. Prostate specific antigen level was 385 μg/L, bone scintigraphy revealed multiple bone metastases, and prostate biopsy confirmed adenocarcinoma (Gleason 9; 4 + 5). Laboratory investigation showed a pattern of enhanced fibrinolysis rather than the more common intravascular coagulation mechanism. Epsilon aminocaproic acid in monotherapy was initiated with a clear and rapid control of bleeding manifestations. This rare case of massive bleeding due to DIC with enhanced fibrinolysis as the first manifestation of prostate cancer suggests that in selected cases where the acute bleeding dyscrasia is clearly associated with a dominant fibrinolysis mechanism it is possible to use an approach of monotherapy with antifibrinolytics.

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RESUMOA intubação orotraqueal (IOT) é um procedimento invasivo complexo que tem como objetivo garantir via aérea segura para adequado suporte ventilatório ao paciente. As principais indicações de IOT na emergência sãos: manutenção de via aérea pérvia, insuficiência respiratória aguda (IRpA), evolução clínica com risco de deterioração, obstrução de via aérea e parada cardiorrespiratória. Como técnica de realização para IOT, a sequência rápida, atualmente é a mais segura para pacientes admitidos em emergência. Dessa forma analisamos os prontuários de todos os pacientes intubados de Janeiro a Dezembro de 2017, identificando a indicação do procedimento, diagnóstico inicial além do tempo entre a IOT e a disponibilização de vaga em Unidade de Terapia Intensiva (UTI).Foram realizadas 174 IOT, dessas, 46,5% foi através de intubação por sequência rápida. 55% das intubações foram por rebaixamento do nível de consciência e 43% por IrpA. Os principais diagnósticos iniciais foram pneumonia (39%) e o AVE (20%). O tempo médio de espera por vaga de UTI foi de 3 a 4 dias, sendo que 38% dos pacientes faleceram antes de conseguir leito em UTI. Apesar do hospital possuir seis leitos na sala vermelha, o número de intubações foi significativo, com média de realização de 1 intubação a cada 2 dias. As principais indicações foram rebaixamento do nível de consciência e IrpA. Além disso, foi observado um longo período de espera por leito em UTI.