A growing number of jurisdictions now request economic data in support of their decision-making procedures for the pricing and/or reimbursement of health technologies. Because more jurisdictions request economic data, the burden on study sponsors and researchers increases. There are many reasons why the cost-effectiveness of health technologies might vary from place to place. Therefore, this report of an ISPOR Good Practices Task Force reviews what national guidelines for economic evaluation say about transferability, discusses which elements of data could potentially vary from place to place, and recommends good research practices for dealing with aspects of transferability, including strategies based on the analysis of individual patient data and based on decision-analytic modeling.
A growing number of jurisdictions are using guidelines for the economic evaluation of pharmaceuticals. The recommendations in existing guidelines regarding the transferability of clinical and economic data are quite diverse. There is a case for standardization in dealing with transferability issues. One important step would be to update guidelines more frequently.
In this paper a new method for solving multicriteria optimization problems by Genetic Algorithms is proposed. Standard Genetic Algorithms use a population, where each individual has the same sex (or has no sex) and any two individuals can be crossed over. In the proposed Multisexual Genetic Algorithm (MSGA), individuals have an additional feature, their sex or gender and one individual from each sex is used in the recombination process. In our multicriteria optimization application there are as many sexes as optimization criteria and each individual is evaluated according to the optimization criterion related to its sex. Furthermore, a multi-parent crossover is applied to generate offspring of parents belonging to all Merent sexes, so the offspring represents intermediate solutions not totally optimal with respect to any single criterion. During the execution of the algorithm the set of nondominated solutions is updated and this set is presented as the output of MSGA at the end.
PurposeThe paper sets out to deal with the off‐line identification of induction motor (IM) parameters at standstill. Determination of values of the IM parameters is essential in sensorless drives with regard to accuracy and quality of the control system.Design/methodology/approachThe presented identification method is based on the reconstruction of stator current response to the forced stator voltage step change; thus the cost function is defined in the classical form of the mean squared error between the computed and experimental data. The identification via evolutionary algorithms (EAs) is presented. The considered problem is continuous and thus a continuous version of EA is suggested as more suitable.FindingsThis approach has been shown to have several advantages over classical optimisation methods like the ability to cope with ill‐behaved problem domains exhibiting attributes such as: discontinuity, time‐variance, randomness, and, what is particularly important in this application, the ability to cope with the signals disturbed by noises. Owing to this ability the EAs could be implemented directly for the identification of IM parameters not only in simulations but also in the industrial applications for the motor control, though the electrical signals acquired from real motor and used as input data in the identification procedures are to a large extent disturbed by the electrical noises.Originality/valueTwo versions of the suggested approach are compared: the EA with hard selection and with soft selection. Both algorithms were tested in a simulation and experimental set‐up using digital signal processor for control and signal processing of the voltage inverter‐fed IM drive. Satisfactory results were obtained for the identification procedure based on the selected EA.
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