Introduction:The importance of multifactorial dysregulation in immune response is well recognised in atopic dermatitis (AD). Th17 family cytokine IL-17 (IL-17A-F) is of significance in both acute and chronic phase of AD. Aim: We analysed the differences between serum levels of IL-17A/F and IL-17A, IL-17-F, IL-13, IL-4, association of rs2275913 IL-17A and rs763780 IL-17F gene polymorphisms in paediatric AD patients and control subjects. Material and methods: We assessed 30 children with AD and 30 healthy patients aged 2-12 years. Eczema Area and Severity Index, Investigator Global Assessment and Scoring Atopic Dermatitis scales were used to analyse the severity of skin lesions in AD patients. Genotyping was performed using PCR and the serum concentrations of IL-17A/F, IL-17A, IL-17F, while IL-13 and IL-4 interleukins were determined by enzyme-linked immuno-sorbent assays (ELISA). Results: The revised median assessment scoring in disease severity showed that the studied AD population had a moderate course of the disease. The obtained results indicated elevated plasma levels of IL-17A/F and IL-17-13 in AD patients with no statistically significance of IL-17A, IL-17F and IL-4 compared to controls. AD duration was positively correlated with IL-13 levels and negatively with IL-17A/F (p < 0.05). Moreover, there was no significant difference between case and control groups in the frequency of genotypes and alleles at rs2275913 IL-17A and rs763780 IL-17F polymorphisms (p > 0.05). Conclusions: This study demonstrates increased levels of IL-17A/F in atopic patients, which is positively correlated with severity of the disease and the early phase of the disease. These results highlight a functional role of this cytokine in the pathogenesis of AD in paediatric patients.
Mastocytozy są bardzo zróżnicowaną grupą chorób nowotworowych, charakteryzującą się nadmierną proliferacją i nagromadzeniem nieprawidłowych mastocytów w jednym lub wielu narządach. Wyróżnia się mastocytozę skórną i układową. W artykule przedstawionoprzypadek 48-letniej pacjentki z rozpoznaną pokrzywką barwnikową, obserwowaną w kierunku mastocytozy układowej.
Introduction: Increasing usage of antimicrobial agents may contribute to bacterial resistance in atopic dermatitis (AD). In this case an alternative topical treatment might be gentian violet (GV), suggested for its antibacterial and antifungal properties. Aim: To assess the microbial composition of lesional skin in children with AD and a control group aged 2-12 years, before and after 3 days of 2% aqueous GV application. Material and methods: Skin samples were taken from 30 AD patients and 30 healthy controls aged 2-12 years. The procedure was done two times -before and after 3 days of 2% aqueous GV application. The material was collected from skin lesions in the cubital fossa using 25 cm 2 impression plates, containing CHROMagar Staph aureus and CHROMagar Malassezia. After the incubation period, the grown colonies were counted and identified by the Phoenix BD testing system. Results: The results revealed a statistically significant reduction in total counts of bacteria in both groups of children after GV application (p < 0.05). The significant decrease in the number was seen in Staphylococcus spp. (S. aureus, S. capitis, S. haemolyticus, S. cohnii) in AD patients. The number of Staphylococcus spp. was comparable in patients with AD after GV treatment and healthy patients before GV exposure (p = 1.000). Conclusions: Our study results show that GV does not damage the skin surface ecosystem and allows the reduction of excessive bacterial counts on eczematous lesions to a 'safe' level, similar to that of healthy children.
Zespół Sneddona-Wilkinsona jest bardzo rzadką, przewlekłą i nawracającą dermatozą, charakteryzującą się występowaniem podrogowych jałowych krost, głównie u osób w starszym wieku. Częstość występowania choroby jest znacznie wyższa u kobiet niż u mężczyzn, a jej przyczyny są nieznane. 75-letnia pacjentka została przyjęta do Kliniki Dermatologii z powodu rozległych zmian o charakterze krost o miękkiej i słabo napiętej pokrywie na rumieniowym podłożu, układającym się w obrączkowate i girlandowate kształty. Przedstawiono różnicowanie z innymi jednostkami chorobowymi oraz możliwości terapeutyczne według aktualnej wiedzy. Rokowanie pogarsza współwystępowanie szpiczaka mnogiego i gammapatii IgA. Należy pamiętać o okresowej kontroli proteinogramu.
Introduction. Bullous pemphigoid is one of the most common autoimmune bullous dermatoses. It is typically diagnosed in elderly patients and can have various clinical presentations. So far, only individual cases of erythema gyratum repens-like bullous pemphigoid have been described in literature worldwide. Objective. Presentation of the case of a patient with bullae forming a wood grain arrangement. Case report. A 76-year-old female patient hospitalised at the Department of Dermatology with erythematous and edematous figurate lesions and tense bullae on the trunk and extremities. On direct immunofluorescence, complement deposits at the basement membrane zone were found. BIOCHIP indirect immunofluorescence revealed circulating anti-BP180 IgG antibodies. Conclusions. In patients with suspected bullous pemphigoid, direct and indirect immunofluorescence assays are required. As part of the diagnosis of both pemphigoid and erythema gyratum repens, malignancy needs to be excluded as a potential cause of skin lesions. In the presented patient, medical history and additional tests did not demonstrate the presence of a neoplasm. The patient requires further clinical follow-up.
Ziarniniak obrączkowaty jest chorobą występującą u osób w młodym wieku o dotychczas nieustalonej etiologii. Wymienia się następujące przyczyny schorzenia: urazy, promieniowanie UV i infekcje. W artykule przedstawiono przypadek 12-letniego chłopcaze zmianami o charakterze ziarniniaka obrączkowatego, które pod wpływem zastosowanej krioterapii ewoluowały w twardzinę ograniczoną.
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