Derivatives of the standard cationic photosensitiser, methylene blue, were synthesised, having extra amino (basic) functionality in the auxochromic side-chain. The resulting analogues were profiled for photodynamic activity in vitro, and screened against standard Gram-positive and Gram-negative bacteria for photobactericidal activity. The substitution pattern of the derivatives was such that ionisation of the amino groups in situ, via protonation, provided a range of charge distribution and degree of charge across the molecular framework. While most examples exhibited greater activity than the lead compound, in addition to similar activity to the known, but more powerful, phenothiazinium photoantimicrobial, dimethyl methylene blue, this was also associated with relatively high dark toxicity, inferring that these compounds were targeting crucial structures before illumination. One derivative having an asymmetrical structure, with separation between a lipophilic and a hydrophilic region exhibited a combination of very high phototoxicity coupled with very low dark effects, against both the standard screen and an additional one containing further, relevant pathogen species, including Candida albicans. It is suggested that the great activity of this analogue is due to efficient membrane targeting.Running header: Basic Phenothiazinium Derivatives
Purpose:The aim of the article was to analyse the correlation between financial liquidity and the competitiveness of enterprises from defense industry enterprises. Design/Methodology/Approach: The solutions were developed on the basis of literature analysis, case study, document analysis. As part of the case study were used diagnostic and prognostic sheets, as well as the analysis of source documents. The analysis of financial liquidity was performed using the induction method, which includes examination of details, generalization in the form of conclusions, synthetic evaluation and diagnosis. The time scope of the research covered the period 2015-2018. Four defense companies in the world were selected for the purpose of the research. Findings: The analysis of four enterprises from the defense industry shows connection between the financial situation (measured by liquidity ratios) and the competitiveness of the surveyed companies. The most stable company, one of the leading defense in the world, is Northrop Grumman. In turn, United Aircraft is characterized by a large dispersion of results and negative values of cash flows from operational activities. The article is also an overview of competitiveness, showing the diversity in managing the resources of an economic unit, and indicates practical guidelines for the use of methods and interpretation of the financial liquidity ratios of enterprises. Practical Implications: The results of the research can be used by company managers, both from the defense industry and others, to create mechanisms that increase competitiveness. Originality/Value: The study is a new contribution to research into the competitiveness of defense companies. The aspects of the competitiveness of defense enterprises on the basis of liquidity ratios remained beyond the area of scientific interest.
W przedsiębiorstwie decydującą rolę w procesie zarządzania ryzykiem odgrywa rachunkowość, która jest jednym z najważniejszych elementów systemu informacyjnego jednostki gospodarczej. Mimo istnienia regulacji, które jasno określają, jak należy postępować, zachowanie polegające na polepszaniu wizerunku firmy, nieujawnianiu ryzyka i zagrożeń wynikających z działalności, a także oszustwa, były, są i będą obecne w życiu gospodarczym. Pierwsze wzmianki o takich sytuacjach pojawiły się niemal natychmiast po powstaniu rachunkowości, odnotowano je już w XVI wieku. Zostały one udokumentowane w dziele O podwójnej buchalterii przez benedyktyńskiego zakonnika Angelo Pietra (Surdykowski, 2005, s. 62). Celem artykułu była prezentacja zjawiska kreatywnej rachunkowości, w szczególności fałszowanie sprawozdań finansowych i jej wpływ na bezpieczeństwo finansowe przedsiębiorstwa. W artykule zastosowano następujące metody badawcze: analizę literatury, studium przypadku, analizę dokumentów.
Operation in the cyberspace of every business unit is unavoidable. Most commercial transactions, marketing activities, e-mail contact with employees or contractors are carried out using virtual space. The purpose of the article is to identify and analyze selected costs for cybersecurity of an enterprise. Costs related to cybersecurity constitute a new category in the management of an enterprise. Considering the costs at the enterprise level, two areas should be discussed: on the one hand, those incurred to prevent cyber threats and on the other one, the costs of offsetting the negative effects of cyber-attacks. For the sake of stable operation and at the same time development in the future, the management should strengthen activities in the field of information security, which is related to costs that will minimize the risk of cyber-attacks.
Cybercriminals during the COVID-19 coronavirus pandemic have redefined both their targets and the form of their cyberattacks. The increased dependence of people around the world on the Internet is driving increasingly bold hacking attacks. Business unit managers are forced to implement better and better security of data resources, which should be organized and at the same time characterized by confidentiality, integrity, and availability. The purpose of the article was to identify and analyse the impact of the COVID-19 pandemic on the cyber security of the business entity. In realizing the purpose of the article, the starting point was a theoretical introduction to cybersecurity. Then, based on the Cybercrime: Covid-19 Impact report developed by Interpol, it was indicated that the coronavirus pandemic has a very high impact on the cyber threat panorama. To analyse the actual market situation, the effects of the cyber-attack on CD PROJEKT Capital Group were analysed.
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