The aim of this study was to obtain bioactive compounds from Mandevilla dardonoi (Apocynaceae), in order to contribute positively to the discovery of new sources of active natural substances. Based on this, the compounds obtained from the ethyl acetate phase were isolated by medium pressure column chromatography and high performance liquid chromatography and identified by nuclear magnetic resonance (1 H) and electrospray mass spectrometry. It was possible to isolate 6 chlorogenic acids: 3-caffeoylquinic (3-ACQ), 4-caffeoylquinic (4-ACQ), 5-caffeoylquinic (5-ACQ), 3,4-dicaffeoylquinic 4-diACQ), 3,5dicaffeoylquinic (3,5-diACQ) and 4,5dicaffeoylquinic (4,5-diACQ) acids. The research contributed positively to the expansion of the knowledge about the genus Mandevilla and especially of the species M. dardonoi, which did not exist reports of phytochemical studies in the literature.
The aim of this study was to obtain bioactive compounds from Mandevilla dardonoi (Apocynaceae), in order to contribute positively to the discovery of new sources of active natural substances. Based on this, the compounds obtained from the ethyl acetate phase were isolated by medium pressure column chromatography and high performance liquid chromatography and identified by nuclear magnetic resonance ( 1 H) and electrospray mass spectrometry. It was possible to isolate 6 chlorogenic acids: 3-caffeoylquinic (3-ACQ), 4-caffeoylquinic (4-ACQ), 5-caffeoylquinic (5-ACQ), 3,4-dicaffeoylquinic 4-diACQ), 3,5dicaffeoylquinic (3,5-diACQ) and 4,5dicaffeoylquinic (4,5-diACQ) acids. The research contributed positively to the expansion of the knowledge about the genus Mandevilla and especially of the species M. dardonoi, which did not exist reports of phytochemical studies in the literature.
ENT-ABIETANE DITERPENES FROM Euphorbia phosphorea (EUPHORBIACEAE). Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpenes jolkinolide A (2), jolkinolide E (3), euphorin H (4), euphopilolide (5) jolkinolide F (6), ent-12-hydroxy-12[R]-abieta8(14),13(15)-dien-16,12-olide (7), ent-11α-hydroxyabieta-8(14),13(15)-dien-16,12α-olide (8), 17-hydroxyjolkinolide B (9) and caudicifolin (10). The structures of all compounds were established using spectroscopic techniques such as 1D and 2D NMR, and the structure of the compound 1 was established also with MS, IR and ECD. All compounds were submitted to an in silico study through of a predictive model and then submitted to in vitro tests against Mycobacterium tuberculosis and M. smegmatis for evaluation of their antimycobacterial activity. Compounds 5 and 9 showed mycobacterial growth inhibition with MIC values of 62.5 μM against M. tuberculosis and M. smegmatis, respectively.
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