Three experiments were performed to explore the relationship between leverpress escape behavior and pituitary-adrenal activity. In Experiment 1, concentrations of plasma corticosterone increased from basal levels during exposure to the shock escape procedure, but were substantially decreased following the 15th escape conditioning session. In Experiment 2, steroid levels of subjects which received inescapable shock remained elevated during exposure to all 15 shock sessions. Experiment 3 examined whether normal pituitary-adrenal arousal was necessary for learning and maintenance of successfulleverpress escape behavior. Subjects for which hypothalamic cortisol implants blocked pituitary-adrenal activity learned the escape response and performed efficiently, although their escape latencies showed a small, but significant, increase over latencies of cholesterol-implanted control subjects. Collectively, these results suggest that pituitary-adrenal activity may reflect rather than mediate the acquisition of coping behavior.

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A total of 391 patients were identified for analysis. The median PSA of all individuals included in the study was 2.05ng/ml. Please refer to table 1 and 2. CONCLUSIONS: The probability of PSMA avid lesions detected on a Ga-68 PSMA PET/CT are correlated to the PSA levels in postprostatectomy patients with biochemical recurrence. Even at low PSA levels (<0.2ng/ml) there is a 42% probability of detecting a PSMA avid lesion, this increases to greater than 90% when PSA levels are >2.0ng/ ml. Further studies are required to investigate how detection of PSMA avid lesions will influence the management of these patients with early disease recurrence.