Gastrointestinal stromal tumors (GISTs) rarely metastasize to the skin. We describe 5 patients with GIST with subcutaneous and cutaneous metastases. The mean age at metastasis was 54 years (range 30-68 years) with a male predominance (4:1). Primary tumors occurred in the stomach (n = 3), small bowel (n = 1), and abdomen, not otherwise specified (n = 1). The average time from primary tumor resection to the resection of skin metastases was 59 months (range 11-155 months). The metastases occurred in the scalp (n = 2), cheek (n = 1), and abdomen (n = 2) with 3 patients presenting with solitary nodules and 2 patients with multiple nodules. The average size was 2 cm (range 0.6-4 cm). Histologically, 2 cases were spindled and 3 cases demonstrated mixed epithelioid and spindle cell morphology. All were confirmed to have CD117 reactivity. KIT genotyping was performed in 4 of 5 cases. Two cases harbored a mutation in exon 11, and the remaining 2 cases were wild type in exons 9, 11, 13, and 17. All 5 patients had multiple concurrent or subsequent abdominal and/or hepatic metastases. In 4 patients with an average follow-up of 32 months (range 6-75 months), after the resection of the metastases, 2 were alive with disease and 2 died of disease. Cutaneous metastases seem to be a late complication of GIST, but their presence does not necessarily herald a rapid demise of the patient.

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Cette expérience a été menée pour évaluer la composition chimique et l'appétence de A. rhomboideus, légumineuse moins connues qui peut avoir le potentiel d'être incluse dans l'alimentation des ruminants en saison sèche comme supplément de foin de faible qualité. La palatabilité du fourrage d'Adenodolichos rhomboideus (O. Hoffm) Harms a été testée en comparaison de celui de Leucaena leucocephala et de Stylosanthes guianensis. Un foin de graminées (Imperata cylindrica et Setaria palude-fusca) a été utilisé comme fourrage de référence. Cette étude a été menée selon la méthode dite « cafétéria » dont l'indice de palatabilité a été estimé en fonction de fourrage de foin selon la formule P = (Ti/Di)/ (T1/D1). Ti et Di sont les quantités de foin consommées et distribuées respectivement. T1 et D1 sont les quantités de légumineuses consommées et distribuées. Les teneurs moyennes en protéines brutes ont été de 100, 132 et 270g/kg MS respectivement pour Stylosanthes, Adenodolichos et Leucaena. Suivant l'indice de palatabilité, le fourrage de Leucaena a été le plus consommé. Les indices de palatabilité des fourrages de Stylosanthes et d'Adenodolichos ont été statistiquement semblables (p<0,05). Adenodolichos rhomboideus présente une faible palatabilité, mais il contient des teneurs en protéines brutes supérieures à la limite recommandée pour l'entretien des ruminants (80 g/kg MS) et supérieures à celle de S. guianensis.

Objective: This study aims at investigating the productive performance, metabolic, and hematological profiles of Algerian local rabbits does during their first pregnancy and according to dietary protein content. Materials and methods: A total of 52 nulliparous rabbit does, 3,116 ± 72.9 g live weight, were allocated individually to three groups (17/18 females per group) being on isoenergetic diets [2,600 kcal Digestible Energy (DE)/kg] that differ in their digestible protein content by 15%, 17%, and 19%, respectively, for L, M, and H diets. All these diets were provided ad libitum . Results: The use of a high protein diet did not affect does weight and feed intake during the pregnancy period. Statistically, no significant difference ( p > 0.05) was recorded in born or alive litter size and birth weight. There was no effect of diet and sampling time ( p > 0.05) on plasma metabolites but there were significant effects of sampling time ( p < 0.0001) on the metabolic parameters studied with prolificacy used as a covariate. Hematologic indices in pregnant rabbits were not affected by the diet exceeded the red blood cells rate that increased significantly ( p < 0.05) with the increase in dietary protein content during the different periods of gestation. Conclusion: The use of a high protein diet has no effect on weight during the pregnancy period. No effect of diet and sampling time on plasma metabolites and hematological profiles are recorded; however, significant effects of sampling time are recorded on the metabolic parameters.