Background: The most common site of prostate cancer metastasesis the bone, followed by the lung, bladder, liver, and adrenal gland. Metastasis from other primary tumours to the pancreas is relatively rare. Here, we report a case of pancreatic metastasis from the prostate.Case presentation:A 52-year-old man was admitted to the hospital with pain in his upper abdomen that had persisted for 20 days. Positron emission tomography/computed tomography examination revealed malignant lesions in the head and tail of the pancreas and a possibility of prostate cancer. Biopsy of the prostate and pancreas were performed,the resultsof which indicated pancreatic metastasis of prostate cancer. After undergoing androgen deprivation therapy and docetaxel chemotherapy for 6 cycles, re-examination revealed that the pancreatic metastases had disappeared. Conclusion:Pancreatic metastatic cancer usually has a poor prognosis, while prostate cancer generally has better outcomes.In this case, the pancreatic metastases disappeared completely following endocrine therapy and chemotherapy. We hope this case will provide a reference for the treatment of similar cases in the future.

Background: To evaluate the surgical effects and oncological outcomes of modified ileal conduit (IC) after radical cystectomy (RC) for bladder cancer.Methods: A single-centre cohort of 211 consecutive bladder cancer patients who underwent RC + modified IC from September 2012 to August 2019 were retrospectively studied. Demographic data, perioperative results, complications 30 and 90 days after surgery and oncological outcomes were recorded. Kaplan–Meier method was used to plot the stage-specific survival results. The 5-year recurrence-free survival (RFS）and overall survival (OS) rate was calculated. Univariate and multivariate Cox regression analyses assessed the predictive risk factors on survival rate.Results: Overall, 211 patients received modified IC after RC. The median operative time (OT) was 315 minutes (IQR, 260–375 minutes), and the median estimated blood loss (EBL) was 500 ml (IQR, 300–900 ml). There were a total of 103 (48.8%) complications. There were 35, 54, 11, and 2 cases of grade I, II, III, and IV complications, respectively; of which 89 cases were grade I and II, accounting for 87.3% of total cases. There were 38 cases of preoperative hydronephrosis and 22 cases of postoperative hydronephrosis. There were 19, 24, 108, 40, and 20 cases of PT0, T1, T2, T3, and T4, respectively, in postoperative pathological stages. The median lymphadenectomy was 14 (IQR, 6–18), and lymph node was found positive in 18 patients. The median follow-up time was 26 months (IQR, 13–43), with a total survival of 177 (83.9%), an RFS of 171 (81%), and 34 deaths. The estimated 5-year OS and RFS rates were 76.80% and 79.10%. Preoperative comorbidities, pathological stage, grade, and lymph node involvement were important influencing factors for OS, while preoperative comorbidities and high pathological grade were important influencing factors for RFS.Conclusions: Modified IC after RC not only can achieve lower postoperative complications, especially the lower incidence of uretero-ileal anastomosis and stoma-related complications but can also achieve the established oncological outcomes of critical radical surgery.

Background: We report our modified surgical technique of retroperitoneal laparoscopic radical nephrectomy (RLRN) and assess its perioperative outcomes and postoperative complications, with a focus on operative time (OT). Methods: We retrospectively analyzed a single-center, single-surgeon cohort of 130 consecutive patients who underwent RLRN between January 2015 and March 2019. A study group of 65 patients who received modified RLRN was compared with a control group of 65 patients who received classical RLRN. OT, estimated blood loss ( EBL ), perioperative complications, postoperative first exhaust time (PFET), pathological stage, and postoperative hospital stay (PHS) were compared between the two groups. Results: All demographic, clinical, and pathological variables were comparable between the groups. No differences were observed in perioperative complications (p=0.648), peritoneal injuries (p=0.843), PFET (p=0.448), pathological stage (p=0.767), and PHS (p=0.304). The modified RLRN group resulted in a significantly reduced overall OT (53.8±8.4 min vs. 60.5±10.6 min, p=0.000), peritoneal injury intervention subgroup OT (56.3±9.8 min vs. 75.2±12.4 min, p=0.000), and EBL (55.7±10.1 mL vs. 62.3±11.6 mL, p=0.001) compared with the classical RLRN group. We observed a significant reduction in OT and EBL but no increase in postoperative complications, PFET, or PHS with modified versus traditional RLRN for localized renal carcinoma.Conclusions: Findings from this study present a modified RLRN surgical technique that is standardized, more precise, and has better practicability.