To measure regional financial service trade and the collaborative relationship between the regional economic development, this paper make full use of synergetics, the entropy weight method and analytic hierarchy process to construct evaluation system, scientific selection of economic structure, economy, the internationalization level index and running environment index, based on the algorithm of EWM in-depth discussion of the system of financial service trade and economic development in Liaoning province cooperative relationship, it provides theoretical support for the next step of Liaoning province's high-quality development. The results show that the regional economic system and financial service trade system of Liaoning province show an alternating m-shape development trend. The synergistic index of regional economic system and regional financial service trade system fluctuates and the synergistic effect of the two subsystems is generally low.