The visual system is thought to separate egocentric and allocentric representations, but behavioral experiments show that these codes are optimally integrated to influence goal-directed movements. To test if frontal cortex participates in this integration, we recorded primate frontal eye field activity during a cue-conflict memory delay saccade task. To dissociate egocentric and allocentric coordinates, we surreptitiously shifted a visual landmark during the delay period, causing saccades to deviate by 37% in the same direction. To assess the cellular mechanisms, we fit neural response fields against an egocentric (eye-centered target-to-gaze) continuum, and an allocentric shift (eye-to-landmark-centered) continuum. Initial visual responses best-fit target position. Motor responses (after the landmark shift) predicted future gaze position but embedded within the motor code was a 29% shift toward allocentric coordinates. This shift appeared transiently in memory-related visuomotor activity, and then reappeared in motor activity before saccades. Notably, fits along the egocentric and allocentric shift continua were initially independent, but became correlated across neurons just before the motor burst. Overall, these results implicate frontal cortex in the integration of egocentric and allocentric visual information for goal-directed action, and demonstrate the cell-specific, temporal progression of signal multiplexing for this process in the gaze system.

The relative contributions of egocentric versus allocentric cues on goal-directed behavior have been examined for reaches, but not saccades. Here, we used a cue conflict task to assess the effect of allocentric landmarks on gaze behavior. Two head-unrestrained macaques maintained central fixation while a target flashed in one of eight radial directions, set against a continuously present visual landmark (two horizontal/vertical lines spanning the visual field, intersecting at one of four oblique locations 11° from the target). After a 100-ms delay followed by a 100-ms mask, the landmark was displaced by 8° in one of eight radial directions. After a second delay (300-700 ms), the fixation point extinguished, signaling for a saccade toward the remembered target. When the landmark was stable, saccades showed a significant but small (mean 15%) pull toward the landmark intersection, and endpoint variability was significantly reduced. When the landmark was displaced, gaze endpoints shifted significantly, not toward the landmark, but partially (mean 25%) toward a virtual target displaced like the landmark. The landmark had a larger influence when it was closer to initial fixation, and when it shifted away from the target, especially in saccade direction. These findings suggest that internal representations of gaze targets are weighted between egocentric and allocentric cues, and this weighting is further modulated by specific spatial parameters.

BackgroundIntersubspecific autotetraploid rice hybrids possess high hybrid vigor; however, low pollen fertility is a critical hindrance in its commercial utilization. Our previous study demonstrated that polyploidy could increase the multi-loci interaction and cause high pollen abortion in autotetraploid rice hybrids. However, there is little known about the critical role of pollen sterility locus or loci in the intersubspecific hybrids. We developed autotetraploid rice hybrids harboring heterozygous genotypes (S i S i S j S j) at different pollen sterility loci by using the near isogenic lines of Taichung65-4×. Moreover, autotetraploid lines carrying double neutral genes, Sa n and Sb n, were used to assess their effect on fertility restoration.ResultsCytological studies showed that the deleterious genetic interactions at Sa and Sb pollen sterility loci resulted in higher pollen sterility (76.83%) and abnormal chromosome behavior (24.59%) at metaphase I of meiosis in autotetraploid rice hybrids. Transcriptome analysis revealed 1092 differentially expressed genes (DEG) in a hybrid with the pervasive interactions at Sa and Sb pollen sterility loci, and most of the genes (about 83%) exhibited down regulation. Of the DEG, 60 were associated with transcription regulation and 18 genes were annotated as meiosis-related genes. Analysis on the hybrids developed by using autotetraploid rice harboring double neutral genes, Sa n and Sb n, revealed normal pollen fertility, and transcriptome analysis showed non-significant difference in number of DEG among different hybrids.ConclusionsOur finding revealed that pervasive interactions at Sa and Sb pollen sterility loci cause high sterility in the autotetraploid hybrids that lead to the down-regulation of important meiosis-related genes and transcription regulation factors. Moreover, we also found that the hybrids sterility could be overcome by double neutral genes, Sa n and Sb n, in autotetraploid rice hybrids. The present study provided a strong evidence for the utilization of heterosis in autotetraploid rice hybrids.Electronic supplementary materialThe online version of this article (10.1186/s12284-017-0188-8) contains supplementary material, which is available to authorized users.

Social media have become increasingly popular for the sharing and spreading of user-generated content due to their easy access, fast dissemination, and low cost. Meanwhile, social media also enable the wide propagation of cyber frauds, which leverage fake information sources to reach an ulterior goal. The prevalence of untrustworthy information sources on social media can have significant negative societal effects. In a trustworthy social media system, trust calculation technology has become a key demand for the identification of information sources. Trust, as one of the most complex concepts in network communities, has multi-criteria properties. However, the existing work only focuses on single trust factor, and does not consider the complexity of trust relationships in social computing completely. In this paper, a multi-criteria trustworthiness calculation mechanism called Info-Trust is proposed for information sources, in which identity-based trust, behavior-based trust, relation-based trust, and feedback-based trust factors are incorporated to present an accuracy-enhanced full view of trustworthiness evaluation of information sources. More importantly, the weights of these factors are dynamically assigned by the ordered weighted averaging and weighted moving average (OWA-WMA) combination algorithm. This mechanism surpasses the limitations of existing approaches in which the weights are assigned subjectively. The experimental results based on the real-world datasets from Sina Weibo demonstrate that the proposed mechanism achieves greater accuracy and adaptability in trustworthiness identification of the network information. INDEX TERMS Multi-criteria, adaptive weight, trust calculation mechanism, information sources, social media.

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