A dose of 2.5 g of gamma-hydroxybutyric acid (GHB) was administered intravenously to 6 healthy male volunteers. A significant increase in plasma GH was observed at 30, 45, 60 and 90 min after injection. The plasma prolactin level increased significantly at 45 and 60 min after GHB injection. These responses were not found after the saline vehicle injection in the same subjects. It is conceivable that GHB could modify the release of serotonin from the nerve terminals and then stimulate the release of GH and prolactin.
gamma-oryzanol (gamma-OZ), a ferulic acid ester of triterpene alcohol, was investigated with regard to its effect on pituitary LH, GH, prolactin and TSH secretion in normal male (M) and ovariectomized female (OVX) rats. gamma-OZ showed a suppressive tendency of LH by a single intravenous injection and also markedly reduced the LH release induced by LHRH when compared with only vehicle-dosed control groups in M and OVX rats. Serum prolactin release induced by TRH was markedly suppressed by 6 days pretreatment with gamma-OZ in OVX rats. These data suggest that gamma-OZ is a potent inhibitor of LH release and may be a weak inhibitor of prolactin in rats.
Gamma-oryzanol (Y-OZ) is a ferulic acid ester of triterpene alcohol and was firstly identified in rice oil by Tsuchiya and Kaneko (1953). The structure of this drug is shown in Fig. 1. This agent has been clinically applied to the patients with climacteric disorders {Miyake Sezaki and Hirabayashi 1963). However, neither the site or mode of action in the endocrinological environment is clear. In the study here, the effect of 7-OZ on pituitary LH secretion and LH response to LHRH was examined in ovariectomized female rats.
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