The electrospinning method was used for the preparation of polymeric nanofibrous layers made of polymers with possible use in the biomedical field. Various samples were prepared using combinations of polycaprolactone or poly(ethylene)oxide and hyaluronic acid. In both cases, nanofibrous layers were spun solely from a water solution. Using confocal Raman spectroscopy we were able to distinguish substantial variations in the distribution of the polymers caused by various preparation parameters and to characterize the prepared samples. Moreover, combining Raman spectroscopy with a mathematical method-singular value decomposition-enabled us to determine the ratios between the polymers used and thus to show the distribution of the present chemical constituents within a localized sample area. This may prove useful for the checking of production of nanofibrous products. Graphical abstract
Analysis of the nanofibers based on Raman spectroscopy and singular value decomposition is presented. The calibration of results is included and local homogeneity of samples is shown through Raman maps. SVD results after and before calibration curve application and recalculation to percents.
The last decade has seen an extensive development of the field of nanomaterials which are currently being used in their first commercial applications. This rapid development is necessarily connected with certain technological demands. This paper describes a technology for the manufacture of nanomaterials from solutions by electrostatic spinning or spraying. Although this method has been well known since the last century, there are still only a few high-quality devices that can be used for the research of new nanomaterials. The main reason for this is that the process of nanomaterials manufacturing is influenced by numerous processing parameters which need to be properly regulated, and furthermore all device components must be resistant to interference from high voltage. The technological requirements are thus stringent. Moreover, such a device must be multifunctional, compact and affordable. This paper describes the technical aspects of a unique laboratory device, i.e., device modules and central control, measured processing parameters, and their effect on the produced materials. The developed laboratory device meets the most demanding criteria for a nanotechnological laboratory device and helps facilitate and speed up the research and development of new nanomaterials produced in high electrostatic field.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.