Graphene materials have unique structures and outstanding thermal, optical, mechanical and electronic properties. In the last decade, these materials have attracted substantial interest in the field of nanomaterials, with applications ranging from biosensors to biomedicine. Among these applications, great advances have been made in the field of antibacterial agents. Here, recent advancements in the use of graphene and its derivatives as antibacterial agents are reviewed. Graphene is used in three forms: the pristine form; mixed with other antibacterial agents, such as Ag and chitosan; or with a base material, such as poly (N-vinylcarbazole) (PVK) and poly (lactic acid) (PLA). The main mechanisms proposed to explain the antibacterial behaviors of graphene and its derivatives are the membrane stress hypothesis, the oxidative stress hypothesis, the entrapment hypothesis, the electron transfer hypothesis and the photothermal hypothesis. This review describes contributions to improving these promising materials for antibacterial applications.
Poly (vinyl alcohol) (PVA) hydrogels are considered promising artificial articular cartilage. However, the weak attachment between PVA hydrogels and subchondral bone limit its application in the biomedical field. In this article, we present a new method to improve the mineralization of PVA hydrogels, and fabricate PVA hydrogels with continuously graded hydroxyapatite coating. The surface of the hydrogels was modified by dopamine self-polymerization and alendronate conjugation subsequently. Based on these, we used simulated body fluids to mineralize the hydrogels to mimic calcified cartilage zone. The modified surface of the PVA hydrogels showed excellent mineralization ability with continuously graded hydroxyapatite (HA). As the main component of human bones, HA can be chemically bonded body tissue on the interface, showing great biological activity. With the content of HA increasing, the cell adhesion ability of the hydrogels was enhanced, which helped the hydrogels integrate tightly with subchondral bone. These results demonstrate that the modified hydrogels could be promising substitutes for articular cartilage.
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