In an attempt to compare crystal structure determination from powder data and single-crystal data, crystal structure of griseofulvin (C 17 H 17 ClO 6 ) was tested by both powder and single-crystal X-ray diffraction. Lattice parameters of griseofulvin are α=90. 0°, a=b=8.9757 Å, c=19.9345 Å, V=1605.99 Å 3 from powder data coinciding with α=90.0°, a=b=8.9714 Å, c=19.8848 Å, V=1600.46 Å 3 from single-crystal data. Main processes of structure elucidating of griseofulvin by the two approaches were analyzed. Powder X-ray diffraction was demonstrated to be a powerful auxiliary implement to single-crystal X-ray diffraction in structure characterization, and its application can be popularized in the field of structure research of small organic molecules.griseofulvin, crystal structure, powder X-ray diffraction, single-crystal X-ray diffraction
Citation:Pan Q Q, Guo P, Duan J, et al. Comparative crystal structure determination of griseofulvin: Powder X-ray diffraction versus single-crystal X-ray diffraction.
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