Our results strongly imply that the spleen is one of the primary sites of synthesis of factor VIII and that the spleen has an inherent ability to fight malignant diseases. Allografting of whole spleen may be a promising technique for the treatment of patients with unresectable hepatocellular carcinoma and severe hemophilia A.
Atomically dispersed
M–N–C has been considered an
effective catalyst for various electrochemical reactions such as oxygen
reduction reaction (ORR) and oxygen evolution reaction (OER), which
faces the challenge of increasing metal load while simultaneously
maintaining catalytic performance. Herein, we put forward a strategy
for boosting catalytic performances of a single Cu atom coordinated
with three N atoms (CuN
3
) for both ORR and OER by increasing
the density of connected CuN
3
moieties. Our calculations
first show that a single CuN
3
moiety exhibiting no catalytic
performance for ORR and OER can be activated by increasing the density
of metal centers, which weakens the binding affinity to *OH due to
the lowered d-band center of the metal atoms. These findings stimulate
the further theoretical design of a two-dimensional compound of C
3
N
3
Cu with a high concentration of homogeneously
distributed CuN
3
moieties serving as bifunctional active
sites, which demonstrates efficient catalytic performance for both
ORR and OER as reflected by the overpotentials of 0.71 and 0.43 V,
respectively. This work opens a new avenue for designing effective
single-atom catalysts with potential applications as energy storage
and conversion devices possessing high density of metal centers independent
of the doping strategy and defect engineering, which deserves experimental
investigation in the future.
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