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To identify hepatocellular carcinoma (HCC)‐implicated long noncoding RNAs (lncRNAs), we performed an integrative omics analysis by integrating mRNA and lncRNA expression profiles in HCC tissues. We identified a collection of candidate HCC‐implicated lncRNAs. Among them, we demonstrated that an lncRNA, which is named as p53‐stabilizing and activating RNA (PSTAR), inhibits HCC cell proliferation and tumorigenicity through inducing p53‐mediated cell cycle arrest. We further revealed that PSTAR can bind to heterogeneous nuclear ribonucleoprotein K (hnRNP K) and enhance its SUMOylation and thereby strengthen the interaction between hnRNP K and p53, which ultimately leads to the accumulation and transactivation of p53. PSTAR is down‐regulated in HCC tissues, and the low PSTAR expression predicts poor prognosis in patients with HCC, especially those with wild‐type p53. Conclusion: This study sheds light on the tumor suppressor role of lncRNA PSTAR, a modulator of the p53 pathway, in HCC.

Technology of HUST for XRD, SEM, TEM, and other measurements. The authors also thanks to the Beamline BL14w1 in SSRF and B12B in NSRL for XAFS and soft XAS measurements. The computational resource was supported by

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The rational design and exploration of the oxygen evolution reaction (OER) electrocatalysts with high efficiency, low cost, and long-term durability are extremely important for overall water splitting. Recently, numerous studies have shown that the OER reaction kinetics can be modified by optimizing components, introducing carbon matrix, and regulating porous nanostructures. Herein, a flexible and controllable electrospinning strategy is proposed to construct porous nitrogen (N)-doped carbon (C) nanofibers (NFs) with nickel−iron (NiFe) alloy nanoparticles encapsulated inside (NiFe@NCNFs) as an OER electrocatalyst. Benefiting from the strong synergistic effects that stem from the one-dimensional mesoporous structures with optimized binary metal components encapsulated in the N-doped carbon nanofibers, the NiFe@NCNFs exhibits enhanced OER performance with a low overpotential (294 mV at 10 mA cm −2 ) and excellent durability (over 10 h at 10 mA cm −2 ) in alkaline solution. Both experimental characterizations and density functional theory (DFT) calculations validate that a suitable binary metal ratio can lead to the optimal catalytic activity. Moreover, a two-electrode electrolyzer is assembled by using NiFe@NCNFs anode and Pt/C cathode in 1.0 M KOH media for the overall water splitting, which delivers an initial cell voltage of only 1.531 V at 10 mA cm −2 , as well as long-term stability up to 20 h. This study sheds light on the design and large-scale production of low-cost and high-performance electrocatalysts toward different energy applications in the future.

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