The influence of sulpiride-induced hyperprolactinemia on the hypothalamic-
pituitary-ovarian function of the baboon (Papio cynocephalus) was investigated. Plasma
levels of prolactin, LH, FSH, estrone, estradiol, 17-hydroxyprogesterone, progesterone
and 20α-dihydroprogesterone in control and consecutive treatment cycles (sulpiride i.m.
injections 100 mg/day) were determined serially. The hormonal changes indicate that the
ovary is the most sensitive site to the direct inhibitory action of sulpiride-induced hyperprolactinemia.
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