RBPs in the development and progression of bladder cancer (BC) remains unclear. Here, we elucidated the role of RBPs in predicting the survival of patients with BC. Clinical information and RNA sequencing data of the training and validation cohorts were downloaded from the Cancer Genome Atlas and Gene Expression Omnibus databases, respectively. Survival-related differentially expressed RBPs were identified using Cox regression analyses. A total of 113 upregulated and 54 downregulated RBPs were observed, with six showing prognostic values (AHNAK, MAP1B, LAMA2, P4HB, FASN, and GSDMB). In both the GSE32548 and GSE31684 datasets, patients with low-risk scores showed longer overall survival than those with high-risk scores. AHNAK, MAP1B, P4HB, and FASN expression were significantly upregulated in both BC tissues and cell lines. BC tissues from the high-risk group showed higher proportions of naïve CD4+ T cells, macrophages M0 and M2, and neutrophils and lower proportions of plasma cells, CD8+ T cells, and T-cell follicular helper compared to the low-risk group. AHNAK knockdown significantly inhibited the proliferation, invasion, and migration of BC cells in vitro and inhibited the formation and growth of subcutaneous tumors in vivo. We thus developed and functionally validated a novel six-RBP-based prognostic model for BC.
In order to perpetuate service sustainability and promote sustainable growth in the service sector, it is important to resolve service failures. AI technology is being applied to service jobs in more and more industries, but AI will inevitably fail while providing service. How to carry out service recovery and obtain the understanding and forgiveness of customers is a problem that urgently needs solving in the practice and research of AI services. The purpose of this study was to explore the artificial intelligence remediation mechanism in the context of service failure and to explore the remedial utility of AI’s self-deprecating humor responses. The study conducted data collection through three experiments to test our hypotheses: study 1 verified the main effect of self-deprecating humor responses and the mediating effect of perceived sincerity and perceived intelligence; study 2 verified the moderated effect of the sense of power; and study 3 verified the moderated effect of failure experience. The experimental results show that, in the context of AI for service recovery, self-deprecating humor responses can improve customers’ willingness to tolerate failure, with perceived intelligence and perceived sincerity found to play a mediating role in this. The sense of power also plays a moderating role by affecting perceived sincerity, and failure experience has a moderate effect by affecting perceived intelligence. The theoretical contribution of the article is to introduce the perspective of AI’s self-deprecating humor service recovery, which complements theoretical research in the field of AI services. The management significance of the article is to provide new AI communication strategies and practical suggestions for enterprises and technical personnel.
The periodontal ligament (PDL) exhibits different material mechanical properties along the long axis of the teeth. To explore the creep and the relaxation effects of dissimilar layers of PDL, this paper took the central incisors of porcine mandibular as experimental subjects and divided them perpendicular to the teeth axis into five layers. Creep experiments and relaxation experiments on five layers were conducted to obtain the creep compliance and relaxation modulus at different layers. Linear elastic model, generalized Kelvin model, and generalized Maxwell model were used to describe the major characteristics of the PDL: Instantaneous elasticity, creep and relaxation. Fitting accuracy of three-parameter, five-parameter, and seven-parameter of the model was compared, and the constitutive equations of different layers were established by the least square method. The results presented that the creep strain and the relaxation stress of PDL were exponentially correlated with time under different loading conditions. Different layers showed a significant effect on the creep strain and relaxation stress of PDL. Along the long axis of the teeth, the changing rule of the creep compliance and relaxation modulus of each layer showed quite the contrary, and the instantaneous elastic modulus first decreased to the minimum, then increased to the maximum. Higher instantaneous elastic modulus led to lower creep compliance and higher relaxation modulus. The generalized Kelvin model and the generalized Maxwell model well characterized the creep and relaxation properties of PDL. Fitting accuracy increased with the number of model parameters. The relaxation time of PDL was about one order of magnitude shorter than the creep retardation time, which indicated that the relaxation effect lasted shorter than the creep effect.
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