Lean NAFLD is a special phenotypic closely correlated with metabolic syndrome (MS). The aim of this study is to investigate the MS development and the gender differences in lean NAFLD population. Participants were divided into 4 groups by BMI and NAFLD status. Descriptive analysis was performed to characterize baseline information. A total of 18,395 subjects were participated, and 1524 incident cases of MS were documented. Then, Kaplan–Meier curves were used to present the MS outcomes in different groups, and the NAFLD was found to be a riskier factor than obesity for MS. Subgroup analysis showed significantly higher MS incidence in female than male among lean NAFLD group, which is different from other groups. Although with higher prevalence in male, lean NAFLD seems to be a more harmful phenotype for females according to the TG, ALT and GGT levels. The logistic regressive analysis was performed to show the impact of NAFLD status and BMI changes on MS risk. Lean non-NAFLD subjects merely developed to NAFLD with no BMI status changes exhibited highest MS risk (ORs = 1.879, 95% CI 1.610–2.292) than that with both BMI increase and NAFLD development (ORs = 1.669, 95% CI 1.325–2.104). It also suggests the metabolic specificity of this population.

The difficulty in the preparation of high-quality rare-earth-doped double-clad chalcogenide glass fiber with high absorption of pumping energy is one of the major issues in the development of mid-infrared fiber lasers. In this study, we solve this problem by changing the inner cladding structure of the fiber. The absorption efficiencies of several typical inner cladding shapes were compared and analyzed by the ray tracing method. The result shows that the hexagonal inner cladding fiber has the best absorption efficiency. For the first time, we developed an Er3+-doped Ge-Ga-Sb-S double-clad chalcogenide glass fiber with a hexagonal inner cladding via the fiber extrusion method, and experimentally demonstrated a higher absorption efficiency in the fiber compared with those in the traditional circular double-clad fibers. Such a hexagonal double-clad chalcogenide glass fiber possesses the potentials for developing high-efficiency mid-infrared fiber lasers.

As the Bragg fiber can guide light by tuning the structure parameters of claddings, it is possible to improve the ability of laser-power transmission in the mid-infrared with effective omnidirectional reflection, but it usually suffers from the disturbance of the air core and functional bandgap. Here, the structural parameters of three pairs of periodic cladding layers were optimized by the plane wave expansion method, and the thickness of each layer is 3.36 µm, consisting of Ge20As20Se15Te45 and As2S3 glasses with a refractive index contrast of Δn = 0.8. The simulation results showed that a wide bandgap of 1.2 µm can be realized in the fiber after structural optimization. Then, a fiber preform was prepared via an improved stacked extrusion based on seven thickness-compensated glass plates. The experimental results show that the all-solid Bragg fiber has three pairs of uniform periodic cladding and an extra-large core. The superior optical fiber structure can also be well maintained in the whole fiber length, and the average ratio of each cladding thickness to the fiber diameter is kept nearly at 3:100. Finally, the fiber loss at 1.55 µm and 2.94 µm is 12 dB/m and 18 dB/m, respectively. In all, such a well-structured all-solid chalcogenide Bragg fiber would pave a new way to develop high-quality laser transmission or optical sensors in mid-infrared.

The complete removal of the impurities like Se-H in Se-based chalcogenide glasses has been challenging in the development of highly transparent chalcogenide glass fiber. In this paper, several purification methods, including dynamic distillation, static distillation, and combined distillation method, were adopted with an aim of purifying arsenic selenide glass with ultra-low content of the impurities. The experimental results demonstrated that the Se-H can be completely eliminated in the arsenic selenide glass host and fiber without the introduction of any chloride. We further explored the applications of such low loss and Se-H-free chalcogenide glass fiber in the mid-infrared. It was found that, using such a Se-H free fiber, a flattened supercontinuum spectrum above the -30 dB level from 1.2 to 13 µm was generated from the Se-H free fiber with a 5.5 µm laser pumping. The sensitivity was found to be improved 5.1 times for CO2 gas in the 3 to 6 µm wavelength range.